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February 10, 2021 Clozapine was 4 times more likely than haloperidol to reduce violence in patients with schizophrenia and conduct disorder, a study published in The American Journal of Psychiatry found .
“This study is the first to examine the effect of clozapine in violent schizophrenia patients with conduct disorder,” researchers wrote. “When conduct disorder is present, clozapine is the optimal treatment.” The 12-week, double-blind study was a head-to-head comparison of clozapine, olanzapine, and haloperidol in 99 patients hospitalized with schizophrenia who were physically assaultive. Researchers categorized patients based on the presence or absence of conduct disorder before age 15 and found that, during the study, those with a history of conduct disorder had more frequent and severe assaults than those without conduct disorder. ....
January 21, 2021 The protein transthyretin (TTR) may play a role in the development of new treatments for Alzheimer’s disease by preventing the formation of amyloid beta clumps, according to a study published in the Journal of Biological Chemistry. Found in amyloid beta clumps, TTR has previously demonstrated an apparent protective effect against the development of Alzheimer’s disease. Mouse studies have shown that animals with more TTR are slower to develop Alzheimer’s-like symptoms, while those with less TTR develop the condition more quickly, researchers explained CREDIT: UT Southwestern Medical Center The new research discovery involves what researchers consider opposing functions of TTR. In healthy individuals, TTR forms a tetramer, a clover-resembling shape with 4 identical leaflets, to help transport thyroid hormone and the vitamin A derivative retinol throughout the body. But when the protein separates into molecules called monomers, TTR can f ....
December 14, 2020 Children and adolescents diagnosed with depression are at increased risk of subsequently developing a wide range of diseases as well as experiencing early death, according to a population-based observational study published in JAMA Psychiatry. Sarah E. Bergen, PhD (Photo courtesy Karolinska Institutet) “Our study shows that children and teenagers diagnosed with depression have a significantly higher risk of premature death, self-harm, and suffering from other diseases later in life,” said researcher Sarah E. Bergen, PhD, of the Karolinska Institutet in Solna, Sweden. “It underscores how important it is that these children and teenagers receive the help they need and that medical personnel monitor for subsequent psychiatric and somatic diseases.” ....