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Little-known protein found to play a role in common neurodegenerative disorder

Scientists have known for years that amyloid fibrils -; fibrous, ropelike structures formed by closely linked protein molecules -; are present in the brains of patients with Alzheimer's and Parkinson's diseases and likely play a role in the progression of these disorders. ....

Yi Xiao Sean Jiang , Pauld Boyer , Michael Sawaya , David Eisenberg , Qin Cao , Emily Henderson , University Of California Los Angeles , Howard Hughes Medical Institute , Mayo Clinic , Molecular Biology , Molecular Biology , Neurodegenerative Disorder , Tdp 43 ,

Potential Protective Role for Protein in Alzheimer's Disease


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A protein that wreaks havoc in the nerves and heart when it clumps together can prevent the formation of toxic protein clumps associated with Alzheimer’s disease, a new study led by a UT Southwestern researcher shows. The findings, published recently in the 
Journal of Biological Chemistry, could lead to new treatments for this brain-ravaging condition, which currently has no truly effective therapies and no cure.
Researchers have long known that sticky plaques of a protein known as amyloid beta are a hallmark of Alzheimer’s and are toxic to brain cells. As early as the mid-1990s, other proteins were discovered in these plaques as well. ....

United States , Joshua Chou , Los Angeles , Lorena Saelices , Peter Odonnell Jr , Wilsony Liang , Danielh Anderson , Qin Cao , University Of California , Brain Institute , Biological Chemistry , Neurodegenerative Diseases , Petero Donnell , ஒன்றுபட்டது மாநிலங்களில் , ஜோஷுவா ச Ou , லாஸ் ஏஞ்சல்ஸ் , பீட்டர் ஓடொன்னேழில் ஜூனியர் , குயின் சாவ் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , மூளை நிறுவனம் , உயிரியல் வேதியியல் ,

Protein that can be toxic in the heart and nerves may help prevent Alzheimer's


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IMAGE: Abnormal deposits of the protein amyloid beta in the brain have been linked to Alzheimer s disease. The above illustration reveals a potential way discovered by UTSW researchers to stop this.
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Credit: UT Southwestern Medical Center
DALLAS - Jan. 7, 2020 - A protein that wreaks havoc in the nerves and heart when it clumps together can prevent the formation of toxic protein clumps associated with Alzheimer s disease, a new study led by a UT Southwestern researcher shows. The findings, published recently in the
Journal of Biological Chemistry, could lead to new treatments for this brain-ravaging condition, which currently has no truly effective therapies and no cure. ....

United States , Joshua Chou , Los Angeles , Lorena Saelices , Peter Odonnell Jr , Wilsony Liang , Danielh Anderson , Qin Cao , University Of California , Brain Institute , Amyloidosis Foundation , Research Executive Agency , Biological Chemistry , Neurodegenerative Diseases , Petero Donnell , People Programme , Marie Curie Actions , European Union , Seventh Framework Programme , Grant Agreement , ஒன்றுபட்டது மாநிலங்களில் , ஜோஷுவா ச Ou , லாஸ் ஏஞ்சல்ஸ் , பீட்டர் ஓடொன்னேழில் ஜூனியர் , குயின் சாவ் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா ,