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A study of gene activity in the brain's hippocampus, led by UT Southwestern researchers, has identified marked differences between the region's anterior and posterior portions. The findings, published today in Neuron, could shed light on a variety of brain disorders that involve the hippocampus and may eventually help lead to new, targeted treatments.
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IMAGE: Marked differences in gene activity were identified in the anterior portion of the hippocampus, which points downward toward the face, and the posterior, which points upward toward the back of. view more
Credit: Melissa Logies
DALLAS - May 28, 2021 - A study of gene activity in the brain s hippocampus, led by UT Southwestern researchers, has identified marked differences between the region s anterior and posterior portions. The findings, published today in
Neuron, could shed light on a variety of brain disorders that involve the hippocampus and may eventually help lead to new, targeted treatments. These new data reveal molecular-level differences that allow us to view the anterior and posterior hippocampus in a whole new way, says study leader Genevieve Konopka, Ph.D., associate professor of neuroscience at UTSW.
Credit: UT Southwestern Medical Center
DALLAS - May 12, 2021 - Scientists with UT Southwestern s Peter O Donnell Jr. Brain Institute have identified the molecular mechanism that can cause weight gain for those using a common antipsychotic medication. The findings, published in the
Journal of Experimental Medicine, suggest new ways to counteract the weight gain, including a drug recently approved to treat genetic obesity, according to the study, which involved collaborations with scientists at UT Dallas and the Korea Advanced Institute of Science and Technology. If this effect can be shown in clinical trials, it could give us a way to effectively treat patients for their neuropsychiatric conditions without this serious side effect, says lead author Chen Liu, Ph.D., assistant professor of internal medicine and neuroscience, and with UTSW s O Donnell Brain Institute and Hypothalamic Research Center.
Scientists identify molecular mechanism behind weight gain in patients taking antipsychotics
Scientists with UT Southwestern s Peter O Donnell Jr. Brain Institute have identified the molecular mechanism that can cause weight gain for those using a common antipsychotic medication. The findings, published in the Journal of Experimental Medicine, suggest new ways to counteract the weight gain, including a drug recently approved to treat genetic obesity, according to the study, which involved collaborations with scientists at UT Dallas and the Korea Advanced Institute of Science and Technology.
If this effect can be shown in clinical trials, it could give us a way to effectively treat patients for their neuropsychiatric conditions without this serious side effect.