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Study: Lung squamous patients harboring druggable mutations have lower median overall survival Oncotarget published Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations which reported that unlike lung adenocarcinoma patients, there is no FDA-approved targeted-therapy likely to benefit lung squamous cell carcinoma patients. The authors performed survival analyses of lung squamous cell carcinoma patients harboring therapeutically relevant alterations identified by whole exome sequencing and mass spectrometry-based validation across 430 lung squamous tumors. They report a mean of 11.6 mutations/Mb with a characteristic smoking signature along with mutations in TP53, CDKN2A, NFE2L2, FAT1, KMT2C, LRP1B, FGFR1, PTEN and PREX2 among lung squamous cell carcinoma patients of Indian descent. ....
4baseCare, Tata Memorial Centre to develop AI based clinical interpretation platform 4baseCare, Tata Memorial Centre to develop AI based clinical interpretation platform 09 January 2021 | News This AI driven tool will support oncologist in clinical decision making and to offer precision medicine to cancer patients Image credit- shutterstock.com 4baseCare, an Illumina Accelerator backed precision oncology startup in Bengaluru and ACTREC (Advanced Centre for Treatment, Research and Education in Cancer) - Tata Memorial Centre (TMC) in Mumbai have signed a collaboration agreement for an AI driven clinical interpretation platform, ClinOme. The collaboration aims at making an indigenous platform to generate data insights and simplified reports to guide oncologists with personalised treatment options for treating cancer patients. ....