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Decreasing DNA repair and genomic instability

Oncotarget published “Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by ....

United States , Mariar Baer , Oncotarget Research Output , Baer Research Team , University Of Maryland , Drug Administration , Veterans Affairs Medical Center , United States Food ,

Impact of BRCA1 mRNA expression on survival of patients breast and colorectal cancer

Oncotarget published "Opposing effects of BRCA1 mRNA expression on patient survival in breast and colorectal cancer and variations among African American, Asian, and younger patients" which reported that LMNB2 is a chromatin remodeling protein that also plays a role in eukaryotic cell proliferation by organizing the nuclear membrane during mitosis. ....

United States , Wafiks El Deiry , Emily Henderson , El Deiry Research Team , Oncotarget Research Output , Lifespan Health System , Brown University , African American , Lifespan Health , Colorectal Cancer , Breast Cancer , Cell Proliferation , Eukaryotic Cell ,

Using CRISPR-Cas9 To Explore Epigenetic Editing in Different Tumor Settings

An increasing number of studies report that proteins do not work in isolation but are part of a complex network of biomolecules, that may differ at various settings or stages of tumor progression. ....

Miguel Vizoso , Jacco Van Rheenen , Vizoso Van Rheenen Research Team , Oncotarget Research Output , Rheenen Research Team ,

TAK1-inhibitors are cytotoxic for multiple myeloma cells

Oncotarget published “TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan” which reported that TAK1 is an ....

Kristiank Starheim , Oncotarget Research Output , Starheim Research Team , Junn Terminal ,

Cytokinome screen of colon cancer cell responses to oncology drugs

Oncotarget published “A high-throughput customized cytokinome screen of colon cancer cell responses to small-molecule oncology drugs” which reported ....

Wafiks El Deiry , El Deiry Research Team , Oncotarget Research Output , Lifespan Health System , Brown University ,