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Study: Lung squamous patients harboring druggable mutations have lower median overall survival

Study: Lung squamous patients harboring druggable mutations have lower median overall survival
Oncotarget published
Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations which reported that unlike lung adenocarcinoma patients, there is no FDA-approved targeted-therapy likely to benefit lung squamous cell carcinoma patients.
The authors performed survival analyses of lung squamous cell carcinoma patients harboring therapeutically relevant alterations identified by whole exome sequencing and mass spectrometry-based validation across 430 lung squamous tumors.
They report a mean of 11.6 mutations/Mb with a characteristic smoking signature along with mutations in TP53, CDKN2A, NFE2L2, FAT1, KMT2C, LRP1B, FGFR1, PTEN and PREX2 among lung squamous cell carcinoma patients of Indian descent. ....

Amit Dutt , Kumar Prabhash , Emily Henderson , Oncotarget Research Output , Dutt Prabhash Research Team , Prabhash Research Team , Squamous Cell Carcinoma , Exome Sequencing , Lung Cancer , Mass Spectrometry , அமித் தத் , குமார் பிரபாஷ் , எமிலி ஹென்டர்சன் , பிரபாஷ் ஆராய்ச்சி அணி ,

Oncotarget: Lung squamous cell carcinoma tumors reveal therapeutic alterations

Lung cancer is the leading cause of cancer-related deaths across the globe with more than 1.7 million deaths annually. ....

Amit Dutt , Kumar Prabhash , Dutt Prabhash Research Team , Prabhash Research Team , Oncotargetresearch Output , Science Math , Medicine Health , Breast Cancer , Prostate Cancer , Policy Ethics , அமித் தத் , குமார் பிரபாஷ் , ஒலி கிளவுட் , பிரபாஷ் ஆராய்ச்சி அணி ,