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Study shows genetically modified pluripotent stem cells may evade immunological rejection after transplantation

Researchers from University of Arizona Health Sciences are one step closer to solving one of the biggest barriers to regenerative medicine: immunological rejection by the recipient. ....

United States , New York , University Of Arizona , Paula Alonso Guallart , Frederickj Monsma Jr , Todda Fehniger , Johnp Atkinson , Deepta Bhattacharya , Shondram Pruett Miller , Hannah Pizzato , James Woods , Jonp Connelly , University Of Arizona Health Sciences Center , York Stem Cell Foundation Research Institute , Washington University School Of Medicine , Uarizona Cancer Center , Tucson Department Of Immunobiology , Uarizona Health Sciences , Uarizona Health Sciences Center , Department Of Immunobiology Deepta Bhattacharya , Diabetes Research Foundation , University Of Arizona Health Sciences , College Of Medicine , Uarizona College Of Medicine , Jude Children Research Hospital , York Stem Cell Foundation ,

Scientists uncover key to enhancing cancer-killing T cells

T cells are the key immune system component involved in killing cancer. Tumors produce signals that turn off these T cells, partially by forcing them to progressively differentiate (mature) into a hypofunctional state known as exhaustion. ....

Jordy Saravia , Peipei Zhou , Shondra Pruett Miller , Hongbo Chi , Hongling Huang , Nicole Chapman , Jonp Connelly , Xiang Sun , Zhao Shi , Cancer Center Support Grant , National Institutes Of Health , Jude Children Research Hospital , Jude Department Of Immunology , Jude Children , Research Hospital , Jude Department , Sujing Yuan , Seon Ah Lim , National Institutes , T Cell , Bone Marrow , Ancer Immunotherapy , Chimeric Antigen Receptor , Ene Expression , Immune System , Transcription Factors ,

Pushing T cells down "memory lane" may improve cancer therapy

/PRNewswire/ Scientists at St. Jude Children s Research Hospital identified a molecular mechanism that in a preclinical study unlocked the promise of CAR. ....

Hongbo Chi , Jasont Yustein , Shondram Pruett Miller , Hongling Huang , Charles Wm Roberts , Swantje Liedmann , Dalia Haydar , Giedre Krenciute , Zhexin Zhu , Zhao Shi , Jonp Connelly , Christopher Derenzo , Piyush Sharma , Markj Chen , Mao Yang , Helen Beere , Yogesh Dhungana , Zhenrui Li , National Cancer Institute , National Institutes Of Health , Jude Department Of Immunology , Baylor College Of Medicine , Jude Department , Sujing Yuan , Jeremy Chase Crawford , Baylor College ,

Pushing T cells down "memory lane" may improve cancer therapy

Scientists at St. Jude Children s Research Hospital identified proteins that help decide T cell fate and used the finding to improve CAR-T cell th. ....

Doug Green , Hongbo Chi , Jasont Yustein , Shondram Pruett Miller , Hongling Huang , Charles Wm Roberts , Swantje Liedmann , Dalia Haydar , Giedre Krenciute , Zhexin Zhu , Zhao Shi , Jonp Connelly , Christopher Derenzo , Piyush Sharma , Markj Chen , Mao Yang , Helen Beere , Yogesh Dhungana , Zhenrui Li , National Cancer Institute , Jude Children Research Hospital , National Institutes Of Health , National Cancer Comprehensive Center , Jude Department Of Immunology , Baylor College Of Medicine , Jude Children ,

ZBP1 links interferon treatment and dangerous inflammatory cell death during COVID-19

/PRNewswire/ Scientists from St. Jude Children s Research Hospital have shown that the innate immune sensor, ZBP1, and its associated inflammatory cell. ....

Bhesh Raj Sharma , Rajendra Karki , Duvvur Nageshwar Reddy , Sanja Trifkovic , Shondram Pruett Miller , Thirumala Devi Kanneganti , Yaqiu Wang , Jacoba Steele , Gella Vishwanath , Mitnala Sasikala , Nagakannan Pandian , Jonp Connelly , Dong Yang , Colleen Beth Jonsson , Sangjoon Lee , Subbarao Malireddi , Peter Vogel , National Institute Of Health , University Of Tennessee Health Science Center , Asian Institute Of Gastroenterology , Jude Department Of Immunology , Jude Department , Raghvendra Mall , Richard Webby , Tennessee Health Science Center , Asian Institute ,