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CCytoskeletal proteins work synergistically in the cell cortex to form intracellular networks

Investigators have discovered that two cytoskeletal proteins which were previously thought to function independently actually interact and form cytoskeletal networks within the cell surface, according to findings published in Proceedings of the National Academy of Sciences. ....

Robert Goldman , Emily Henderson , Proceedings Of The National Academy Sciences , Division Of Pulmonary Care , Northwestern University , National Academy , Developmental Biology , Pulmonary Care , Comprehensive Cancer Center , Developmental Biology ,

Research looks at inflammatory nature of lipid nanoparticle component in mRNA vaccines

Research looks at inflammatory nature of lipid nanoparticle component in mRNA vaccines
Lipid nanoparticles (LNPs) are the carrier vehicles that protect messenger RNA (mRNA) molecules from degradation and aid intracellular delivery and endosomal escape in the nucleoside-modified mRNA-LNP vaccine platforms currently used by Pfizer/BioNTech and Moderna, against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These two vaccines surpass the rest with their effective support for T follicular helper cells (Tfh) and the protective humoral responses observed in the preclinical trials.
While the vital role of LNPs in these vaccines action is established, the potentially inflammatory nature of these LNPs is not assessed. Also, in the Pfizer/BioNTech and Moderna vaccines human trials, it is reported that side effects often linked to inflammation, such as pain, swelling, fever, and sleepiness, are common. ....

Botondz Igy , Ramya Dwivedi , Thomas Jefferson University , Corona Virus , Immune Response , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ரம்யா டுவிவேடி , தாமஸ் ஜெஃபர்சன் பல்கலைக்கழகம் , நானோ துகள்கள் , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Plant Cell Receptors join Forces to beat Bacterial Invasion Labmate Online

Plant Cell Receptors join Forces to beat Bacterial Invasion
Mar 13 2021 Read 2685 Times
In a study to understand better how plants defend themselves against bacterial pathogens, researchers at The Sainsbury Laboratory (TSL) have been able to unravel the roles played by two different cell receptors that normally work together to initiate an immune response.
Receptors at the cell surface detect pathogen-derived molecules that accumulate outside plant cells; this activates pattern-triggered immunity (PTI). PTI, however, is suppressed by pathogen-derived effector proteins, that are injected into host cells to enable pathogen growth. In response, the invading effectors can be detected by intracellular receptors in the plant which results in effector-triggered immunity (ETI). Until now, it has not been clear how the defence mechanisms activated by these two distinct perception mechanisms interact. ....

Jonathan Jones , Sainsbury Laboratory , Chinese Academy Of Sciences , Bruno Pok Man Ngou , Professor Jonathan Jones , Chinese Academy , Pok Man Ngou , Plant Immunity , ஜொனாதன் ஜோன்ஸ் , சைன்ஸ்பரி ஆய்வகம் , சீன கலைக்கழகம் ஆஃப் அறிவியல் , ப்ரொஃபெஸர் ஜொனாதன் ஜோன்ஸ் , சீன கலைக்கழகம் , ஆலை நோய் எதிர்ப்பு சக்தி ,

Structure and function of locked conformation of the SARS-CoV-2 spike protein identified

A new preprint research paper, posted to the bioRxiv server, uncovered more information on the different structural conformations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The findings suggest the spike protein turns into a locked state to stabilize the spike protein during virus egress. ....

Jocelyn Solis Moreiramar , Jocelyn Solis Moreira , Sars Cov 2 , Spike Protein , Corona Virus , Coronavirus Disease Covid 19 , Linoleic Acid , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , ஸ்பைக் ப்ரோடீந் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Researchers use EPR spectroscopy to learn more about "Parkinson protein"

Researchers use EPR spectroscopy to learn more about Parkinson protein
The protein α-synuclein is one of the most abundant proteins in the human brain. It is often referred to as the Parkinson protein , as deposition of this protein in brain cells is a hallmark of Parkinson s disease.
Despite the high interest of biomedical research in the protein, many questions concerning the function and physiology of α-synuclein in living cells still remain to be answered. For example, it was previously unclear whether and to what extent the protein binds to and interacts with internal cell components such as membranes.
As such processes could play a role in the development of the disease, the team led by Konstanz-based physical chemist Professor Malte Drescher used the further development of an established measurement method called electron paramagnetic resonance spectroscopy (EPR spectroscopy) to learn more about the binding properties of the Parkinson protein . ....

Juliane Stehle , Theresa Braun , Emily Henderson , University Of Konstanz , Professor Malte Drescher , Physical Chemistry , Physical Chemist , In Vitro , Living Cells , Parkinson 39s Disease , தெரேசா மூளை , எமிலி ஹென்டர்சன் , ப்ரொஃபெஸர் மால்ட் திரெஸ்சேற் , உடல் வேதியியல் , உடல் வேதியியலாளர் , எதிர் மின்னணு , இல் விட்ரோ , வாழும் செல்கள் ,