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Researchers investigate protein phosphatase to identify new treatments for cancer, other diseases


Researchers investigate protein phosphatase to identify new treatments for cancer, other diseases
The abundant presence of an enzyme known as low molecular weight protein tyrosine phosphatase (LMWPTP) in tumor cells has long been considered an indicator of cancer aggressiveness and metastatic potential. It is also known to perform important functions in cells under normal conditions, participating in both the proliferation process and the regulation of intracellular systems. Research continues on its role in cancer progression.
In Brazil, a group of researchers at the University of Campinas s In Vitro Bioassay and Signal Transduction Laboratory led by Professor Carmen Veríssima Ferreira-Halder are studying the possibility of inhibiting this protein phosphatase to create novel opportunities for monitoring and treatment of cancer and other diseases. ....

Erasmus Mc Moniek , Emanuella Maria Barreto Fonseca , Nunzio Bottini , Helon Guimar , Sousa Faria , Sheila Siqueira Andrade , Emily Henderson , University Of California San Diego , University Of Campinas In Vitro Bioassay , Molecular Life Sciences , Transduction Laboratory , University Of Campinas , Vice Rectorship For International Relations , Vitro Bioassay , Signal Transduction Laboratory , Professor Carmen Ver , Thematic Project , Professor Maikel Peppelenbosch , Erasmus University Medical Center , Alessandra Val , California San Diego , Executive Vice Rectorship , Stefano Piatto Clerici , Plateinnove Biotech , Moniek De Maat , Gwenny Fuhler ,

CytoDel successfully delivers neuronal antibody in animal models of botulism


CytoDel successfully delivers neuronal antibody in animal models of botulism
CytoDel, Inc. ( CytoDel or the Company ), a privately-held corporation, today announces the publication of preclinical data on the Company s lead product, Cyto-111, in the peer-reviewed journal,
Science Translational Medicine. The complete text of the article titled, Neuronal Delivery of Antibodies has Therapeutic Effects in Animal Models of Botulism, can be found here.
Cyto-111 was conceived, expressed and purified in the laboratory of Konstantin Ichtchenko, Ph.D., NYU Grossman School of Medicine, Department of Biochemistry and Molecular Pharmacology, who was a principal investigator in the study, which was supported by grants from the National Institute of Allergy and Infectious Diseases (NIAID), a division of the National Institute of Health (NIH). ....

Konstantin Ichtchenko , Emily Henderson , School Of Medicine , Research Professor , National Institute Of Health , National Institute Of Allergy , Department Of Biochemistry , Cytodel Inc , Tufts University Center , Grossman School Of Medicine , Department Of Molecular , Behavioral Sciences At Stanford University , Howard Hughes Medical Institute , Science Translational , Therapeutic Effects , Animal Models , Molecular Pharmacology , National Institute , Infectious Diseases , Cellular Physiology , Behavioral Sciences , Stanford University , Scientific Advisory , Translational Medicine , Medical Research Institute , Chemical Defense ,