Researchers at the Icahn School of Medicine at Mount Sinai have identified an allergy pathway that, when blocked, unleashes antitumor immunity in mouse models of non-small cell lung cancer (NSCLC).
<p style="text-align:justify">Researchers at the Icahn School of Medicine at Mount Sinai have identified an allergy pathway that, when blocked, unleashes antitumor immunity in mouse models of <em>non-small cell lung cancer (</em>NSCLC)<em>. </em> And in an early parallel study in humans, combining immunotherapy with dupilumab<em>—</em>an <a href="https://www.frontiersin.org/articles/10.3389/fimmu.2018.00888/full" target=" blank">Interleukin-4</a> (IL-4) receptor-blocking antibody widely used for treating allergies and asthma<em>—</em>boosted patients' immune systems, with one out of the six experiencing significant tumor reduction. The findings were described in the December 6 issue of<em> Nature.</em></p>
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Ronnie O’Sullivan to face debutant Mark Joyce in World Championship opener
Ronnie O’Sullivan is the defending champion (Nigel French/PA)
Ronnie O’Sullivan will open the defence of his Betfred World Snooker Championship title against debutant Mark Joyce at the Crucible.
Veteran Joyce, 37, turned professional in 2006, but had never previously made it through to the showpiece tournament, securing his place with victory over Brazil’s Igor Figueiredo in the last qualifying round.
Elsewhere in Thursday’s draw, former champion Stuart Bingham, another who came through qualifying, will meet China’s Ding Junhui, while world number one Judd Trump plays Liam Highfield.