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Oncofetal ecosystems linked to recurrence and immunotherapy response in liver cancer

A team of clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS), Agency for Science, Technology and Research (A STAR), the Harry Perkins Institute of Medical Research and global research partners, has found a causal link between the presence of oncofetal ecosystems (re-emergence of fetal programme/features driven by the tumor) in the primary liver cancer hepatocellular carcinoma (HCC) and cancer recurrence and response to immunotherapy. ....

Western Australia , Florent Ginhoux , Ankur Sharma , National Cancer Centre Singapore , Lab Head Of The Onco , Harry Perkins Institute Of Medical Research , Singapore Immunology Network , Research Council , Translational Research Investigator Award , Fetal Ecosystem Laboratory , Biomedical Research Council , National Research Foundation Singapore , Singapore National Research Foundation Senior Investigatorship , National Health , Research Future Fund , Agency For Science , Harry Perkins Institute , Medical Research , Nature Cancer , Slab Head , Onco Fetal Ecosystem Laboratory , Associate Professor Florent Ginhoux , Senior Principal Investigator , Immunology Network , Professor Pierce Chow , Senior Consultant Surgeon ,

Back to the future: Weizmann Institute scient

<p>In a new study published today in <em>Cell</em>, researchers from Prof. Ido Amit&#39;s lab at the Weizmann Institute of Science have managed for the first time to develop a method for tracking and measuring changes over time on in single cells inside the body. The method, called Zman-seq (from the Hebrew word <em>zman</em>, for &ldquo;time&rdquo;), consists of labeling cells with different time stamps and tracking them in healthy or pathological tissue. Using this cellular time machine, researchers can get to know the cells&rsquo; history and how long each cell had stayed in the tissue, ultimately achieving an understanding of the molecular and cellular temporal changes that had taken place within that tissue.</p>
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Ido Amit , Katayoun Rezvani , Fabianj Theis , Daniel Kirschenbaum , Marco Colonna , Albert Einstein , Ken Xie , Florent Ginhoux , Tobias Weiss , Florian Ingelfinger , Nir Yosef , Dwek Institute For Cancer Therapy Research , Helmholtz Center Munich , Weizmann Institute Of Science , Morris Kahn Institute For Human Immunology , Shanghai Institute Of Immunology , Moross Integrated Cancer Center , Washington University , Institute For Cancer Diagnosis Research , Schwartz Reisman Collaborative Science Program , Weizmann Systems Immunology Department , Swiss Society Institute For Cancer Prevention Research , University Hospital Zurich , John Hecht Memorial Foundation , University Of Texas , Weizmann Institute ,