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In Down syndrome cells, genome-wide disruptions mimic a senescence-like state

The disruption of gene transcription and cell function in Down syndrome is very similar to that seen in cellular aging, MIT scientists find. They used anti-senescence drugs to correct the errors in cell cultures, establishing senescence as a potentially targetable mechanism for future treatment. ....

United States , Ashley Watson , Lindsey Guerin , Angelika Amon , Asaf Marco , Vishnu Dileep , Hiruy Meharena , Jacob Jaffe , Li Huei Tsai , Shruti Rengarajan , Malvina Papanastasiou , Elana Lockshin , Fatema Abdurrob , James Mullahoo , Alana Down Syndrome Center , Burroughs Wellcome Fund , Lumind Foundation , National Institutes Of Health , Jalana Center , Picower Institute For , Alana Foundation , University Of California At San Diego , Cell Stem , Senior Alana Fellow , Picower Professor , Picower Institute ,

Down Syndrome Ages Cells Throwing Neural Nuclei into Disarray

MIT scientists show that the extra copy of chromosome 21 in Down syndrome disrupts the 3D-genome, epigenome, and transcriptome of neural progenitor cells such that they resemble aged cells. The molecular changes result in functional deficits in cell proliferation and migration in the trisomy 21 bearing developmental cells. Treatment of patient-derived neural progenitor cells with a senolytic drug combination consisting of dasatinib and quercetin ameliorates these disruptions. ....

United States , San Diego , Anita Bhattacharyya , Hiruy Meharena , Li Huei Tsai , University Of California , Alana Down Syndrome Center , Burroughs Wellcome Fund , Lumind Foundation , Massachusetts Institute Of Technology , National Institutes Of Health , Jalana Center , Picower Institute For , Alana Foundation , University Of Wisconsin , Massachusetts Institute , Cell Stem , Picower Institute , National Institutes ,

Study suggests new cause of Down syndrome: cells linked to aging

MIT scientists may have found a surprising culprit for Down syndrome: senescent cells, the same types implicated in many diseases of aging. ....

United States , Tamir Chandra , Hiruy Meharena , Li Huei Tsai , Alana Down Syndrome Center , University Of Colorado , Massachusetts Institute Of Technology , University Of San Diego , Picower Institute For , University Of Edinburgh , Massachusetts Institute , Cell Stem , Picower Institute , Chris Link ,

Diverse Junior Scientists Display Their Talents and Learn to Navigate Academia

February 17, 2021
by Jeanna Lucci-Canapari
A multi-institution symposium led by Yale School of Medicine treated more than 1,900 online participants from across the country to a showcase of research from a diverse group of talented postdoctoral researchers, with the goal of propelling their promising careers in scientific discovery. The Intersections Science Fellows Symposium was held through Zoom sessions and webinars from January 6 through 8, and was hosted by a coalition formed by Yale and 25 other national research institutions.
The symposium featured the research contributions from 26 junior scientists, who were chosen to present their work as 2021 Intersection Science Fellows. Selected from a pool of more than 400 applicants, the fellows largely represented communities that have been historically unrepresented in the field of medical research, including those from ethnic and racial minorities, those with disabilities, those from low socioeconomic backgrounds, wome ....

Caroline Hendry , Snusha Ravikumar , Yadira Soto Feliciano , Fergusf Wallace , Hiruy Meharena , Antonio Giraldez , Rochelled Smith , Darin Latimore , Sherree Wilson , Yale School Of Medicine , Rockefeller University , Washington University School Of Medicine , Yale School , Intersections Science Fellows Symposium , Washington University School , Both Latimore , கரோலின் ஹென்ட்ரி , யாதிரா ஸோடோ ஃபெலிசியானோ , டரின் லாடிமோர் , யேல் பள்ளி ஆஃப் மருந்து , ராக்ஃபெல்லர் பல்கலைக்கழகம் , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , யேல் பள்ளி , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி , இரண்டும் லாடிமோர் ,