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Bulevirtide monotherapy 'may prevent decompensation but not HCC' in HDV, cirrhosis

Over 2 years, bulevirtide monotherapy reduced the risk for decompensation and mortality, but not hepatocellular carcinoma, among patients with hepatitis D virus and compensated cirrhosis compared with untreated patients.
“Bulevirtide, the first-in-class entry inhibitor, has been approved by EMA for treatment of compensated chronic hepatitis delta,” Elisabetta Degasperi, MD, ....

Kristen Dowd , Bykate Burba , Granda Ospedale Maggiore Policlinico ,

'Substantial proportion' of PSC patients listed for LT due to dysplasia have no neoplasia

Researchers identified bile duct dysplasia or cancer in most explanted livers with an indication of biliary dysplasia, although as many as 41% had no signs of neoplasia, according to a study of patients with primary sclerosing cholangitis.
“Primary sclerosing cholangitis, in short PSC, is one of the leading causes of liver transplantation in the Nordic countries with a high risk of ....

Sigurd Breder , Heather Biele , Bykate Burba , Research Center , Nordic Liver Transplant Registry ,

Mebeverine not superior to placebo in pediatric IBS; active drug labeling improved efficacy

Mebeverine not superior to placebo in pediatric IBS; active drug labeling improved efficacy
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United States , Noord Holland , Heather Biele , Bykate Burba , Marca Benninga , Digestive Disease Week ,

Endoscopic, histologic improvements in EoE sustained at 52 weeks with etrasimod

WASHINGTON — Once-daily etrasimod 1 mg and 2 mg was well-tolerated and sustained improvements in histological and endoscopic features of eosinophilic esophagitis, as well as patient symptoms, through 52 weeks of treatment, according to data.
“Etrasimod is a an oral, once-daily selective sphingosine 1-phosphate receptor modulator for the treatment of moderately to severely active ....

United States , Bykate Burba , Evans Dellon , Heather Biele , University Of North Carolina School Medicine , Esophageal Diseases , North Carolina School , Digestive Disease , Digestive Disease Week , Eoe Histology Scoring System , Eoe Endoscopic Reference Score , Patient Global Impression , Dysphagia Symptom Questionnaire ,

Blood-based screening test detects CRC with nearly 80% sensitivity in average-risk adults

WASHINGTON — A blood-based screening test detected colorectal cancer with a sensitivity of 79.2% and a specificity of 91.5% among average-risk adults aged 45 to 85 years, according to research presented at Digestive Disease Week.
“Adherence to colon cancer screening tests is suboptimal with current options of stool-based tests and colonoscopy,” Aasma Shaukat, MD, MPH, director ....

District Of Columbia , United States , Aasma Shaukat , Heather Biele , Maryh Glickman , Bykate Burba , Grossman School Of Medicine , Digestive Disease , Digestive Disease Week ,