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Novel ADCs Must Keep Up With Moving Targets in Metastatic Breast Cancer

Barbara Pistilli, MD, discusses the mechanism of action of novel ADCs, the ways in which ADC targets in breast cancer can change over time, and how future research may pave the way for individualized treatment with this class of agents. ....

France General , Barbara Pistilli , Breast Disease Committee , Medical Oncology , Gustave Roussy Cancer Center , Antibody Drug Conjugates , Breast Cancer , Phase 2 Daisy Trial Nct04132960 ,

Benefits of ivosidenib regimen for IDH1 -mutant AML increase with longer follow-up

CHICAGO — Ivosidenib extended median OS more than three times longer than placebo when added to azacitidine for adults with treatment-naive, IDH1-mutated acute myeloid leukemia, according to updated results of the phase 3 AGILE trial.The long-term follow-up data, presented at ASCO Annual Meeting, showed an additional 5-month increase in median OS with the ivosidenib (Tibsovo, Servier) ....

United States , Astellas Amgen Biopharama , Mindy Valcarcel , Bydevin Mclaughlin , Bristol Myers Squibb , Gustave Roussy Cancer Center , Jazz Pharmaceuticals , Amgen Biopharama , Auron Therapeutics , Forma Therapeutics , Loxo Oncology , Remix Therapeutics ,