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Novel ADCs Must Keep Up With Moving Targets in Metastatic Breast Cancer

Barbara Pistilli, MD, discusses the mechanism of action of novel ADCs, the ways in which ADC targets in breast cancer can change over time, and how future research may pave the way for individualized treatment with this class of agents. ....

France General , Barbara Pistilli , Breast Disease Committee , Medical Oncology , Gustave Roussy Cancer Center , Antibody Drug Conjugates , Breast Cancer , Phase 2 Daisy Trial Nct04132960 ,

Dr Pistilli on Understanding Dynamic HER2 Expression in Metastatic Breast Cancer

Barbara Pistilli, MD, discusses the importance of understanding how HER2 expression can change over time when assessing target expression in metastatic breast cancer.
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Barbara Pistilli , Breast Disease Committee , Gustave Roussy Institute ,

HER3+ CTC Count May Affect Responses to Patritumab Deruxtecan in Pretreated Advanced Breast Cancer

Higher baseline HER3-positive circulating tumor cell count at baseline and reduction following treatment initiation was associated with a higher likelihood of deriving an early response with patritumab deruxtecan in patients with hormone receptor–positive or HER2-low advanced breast cancer. ....

France General , Gustave Roussy , Barbara Pistilli , Breast Cancer Annual Congress , Cancer Annual , Breast Cancer , The 2023 Esmo Breast Cancer Annual Congress , Phase 2 Icarus Breast01 Trial Nct04965766 , Patritumab Deruxtecan , Her3 Positive Circulating Tumor Cell Count ,