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Natural killer cell therapies

Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK cells is their ability to recognize a wide range of cells in distress, particularly tumour cells and cells infected with viruses. They combine both direct effector functions against their cellular targets and participate in the generation, shaping and maintenance of a multicellular immune response. As our understanding has deepened, several therapeutic strategies focused on NK cells have been conceived and are currently in various stages of development, from preclinical investigations to clinical trials. Here we explore in detail the complexity of NK cell biology in humans and highlight the role of these cells in cancer immunity. We also analyse the harnessing of NK cell immunity through immune checkpoint inhibitors, NK cell engagers, and infusions of preactivated or genetically modified, autologous or allogeneic NK cell products. This Review explores in detail the complexity of NK cell biology i ....

Ad Jr Maus , Medjouel Khlifi , Sen Santara , Preprint At Research Square , Natl Cancer Inst , Research Square , Cell Sci , Cancer Res , Cancer Ther , Stem Cell , Growth Factor Rev , Leukocyte Biol ,

Circulating myeloid-derived MMP8 in stress susceptibility and depression

Psychosocial stress has profound effects on the body, including the immune system and the brain1,2. Although a large number of pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders such as major depressive disorder (MDD)3, the underlying mechanisms are not well understood. Here we show that expression of a circulating myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is increased in the serum of humans with MDD as well as in stress-susceptible mice following chronic social defeat stress (CSDS). In mice, we show that this increase leads to alterations in extracellular space and neurophysiological changes in the nucleus accumbens (NAc), as well as altered social behaviour. Using a combination of mass cytometry and single-cell RNA sequencing, we performed high-dimensional phenotyping of immune cells in circulation and in the brain and demonstrate that peripheral monocytes are strongly af ....

United States , South Korea , Lookeren Campagne , Brunstein Klomek , J Health Soc , Research Version American Psychiatric Association , Psychiatry Rep , Cancer Biol , Open Sci , Growth Factor Rev , Cell Biol , Structured Clinical Interview , American Psychiatric Association ,

Tremelimumab plus durvalumab retreatment and 4-year outcomes in patients with mesothelioma: a follow-up of the open label, non-randomised, phase 2 NIBIT-MESO-1 study

Tremelimumab plus durvalumab retreatment and 4-year outcomes in patients with mesothelioma: a follow-up of the open label, non-randomised, phase 2 NIBIT-MESO-1 study
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Chemother Pharmacol , World Health Organization , Bull World Health Organ , World Health Organ , Clin Oncol , Mesothelioma Avastin Cisplatin Pemetrexed Study , Respir Med , Growth Factor Rev , Rev Immunol , Clin Med , Englj Med , உலகம் ஆரோக்கியம் ஆர்கநைஸேஶந் , காளை உலகம் ஆரோக்கியம் ஆர்கந் , உலகம் ஆரோக்கியம் ஆர்கந் , வளர்ச்சி காரணி ரெவ் , கிளினிக் மேட் ,