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Circulating myeloid-derived MMP8 in stress susceptibility and depression

Psychosocial stress has profound effects on the body, including the immune system and the brain1,2. Although a large number of pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders such as major depressive disorder (MDD)3, the underlying mechanisms are not well understood. Here we show that expression of a circulating myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is increased in the serum of humans with MDD as well as in stress-susceptible mice following chronic social defeat stress (CSDS). In mice, we show that this increase leads to alterations in extracellular space and neurophysiological changes in the nucleus accumbens (NAc), as well as altered social behaviour. Using a combination of mass cytometry and single-cell RNA sequencing, we performed high-dimensional phenotyping of immune cells in circulation and in the brain and demonstrate that peripheral monocytes are strongly af ....

United States , South Korea , Lookeren Campagne , Brunstein Klomek , J Health Soc , Research Version American Psychiatric Association , Psychiatry Rep , Cancer Biol , Open Sci , Growth Factor Rev , Cell Biol , Structured Clinical Interview , American Psychiatric Association ,

Frontiers | Characterizing the Relationship Between the COVID-19 Pandemic and U.S. Classical Musicians' Wellbeing

The COVID-19 pandemic has devastated the economic and social wellbeing of communities worldwide. Within the general population, certain groups are at greater risk than others, namely, persons with pre-existing mental disorders and those disproportionately impacted by the economic strain of the pandemic (Diaz et al. 2021; Calderón-Larrañaga et al. 2020) . Classical musicians, who bear a disproportionately high incidence of mental illnesses, and whose subsistence is primarily reliant upon live performances (van Fenema and van Geel 2014), fall into both categories. The COVID-19 pandemic has greatly harmed the classical music industry, silencing the world’s concert halls and theatres. In an industry characterized by instability, a shock as great as COVID-19 may bring negative effects that far outlast the pandemic itself. This study investigates the wellbeing of classical musicians during the COVID-19 pandemic. 68 professional classical musicians completed a questionnaire compos ....

United Kingdom , South Korea , Government Printing Office , District Of Columbia , United States , New York , City Of , San Francisco , South Lanarkshire , Los Angeles , Vest Agder , John Wiley , Souza Crippa , Rr Core Team , Sciences Faculty Research , Los Angeles Times , J Community Psychol , Public Health , J Health Soc , J Health Social Behav , Us Government Printing Office , J Urban Health Bull , Stanford University School Of Humanities , Health New York , Stanford University Institutional Review Board , Stanford University Institutional Review Board Protocol ,

Frontiers | Sick or Sad? A Qualitative Study on How Dutch GPs Deal With Sadness Complaints Among Young Adults

Frontiers | Sick or Sad? A Qualitative Study on How Dutch GPs Deal With Sadness Complaints Among Young Adults
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United States , United Kingdom , Thousand Oaks , North Yorkshire , Den Haag , Zuid Holland , De Mheen , City Of , The Netherlands , Voor Maatschappelijk Probleem , Nederlands Huisartsen Genootschap , Ziek Van Gezondheid , Volksgezondheid Toekomst Verkenning , Peter Conrad , University Of California , Mental Health , Substitution Of Mental Health Care , Ministry Of Health , Dutch National Institute For Public Health , University Of North Carolina , Practice Nurse Mental Health , J Health Soc , Princeton University Press , Nursing Research , Dutch College , Health Illn ,

Frontiers | Punishment on Pause: Preliminary Evidence That Mindfulness Training Modifies Neural Responses in a Reactive Aggression Task

Frontiers | Punishment on Pause: Preliminary Evidence That Mindfulness Training Modifies Neural Responses in a Reactive Aggression Task
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New York , United States , Virginia Commonwealth University , T Phillips Ingenia , Basic Books , Translational Sciences , J Health Soc , Montreal Neurological Institute , University Of Virginia , J Health Psychol , National Center , National Institutes Of Health , University Of Virginia Contemplative Sciences Center , Institutional Review Board Of Virginia Commonwealth University , National Institute On Alcohol Abuse , Reduce Reactive , General Aggression Model , Its Regulation Using , Taylor Aggression Paradigm , Perceived Stress Scale , Institutional Review Board , Aggressive Motives Scale , Aggressive Pleasure Scale , Functional Neuroimages , Advancing Translational Sciences , National Institute ,

Frontiers | Identifying Resilience Factors of Distress and Paranoia During the COVID-19 Outbreak in Five Countries

Frontiers | Identifying Resilience Factors of Distress and Paranoia During the COVID-19 Outbreak in Five Countries
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New York , United States , United Kingdom , San Francisco , Møg Romsdal , Universidad Nacional De Colombia , Distrito Capital , Minas Gerais , Adhanom Ghebreyesus , Abdul Rahim , Grosse Holtforth , E Diener Dordrecht , Ciencias Humanas Universidad Nacional , Ed Diener , Rr Core Team , Mental Health , Un Sustainable Development Solutions Network , Ben Gurion University , Public Health , Cambridge University Press , J Health Soc , Womens Health , Item Community Assessment Of Psychic , Health Psychol , Risk Factors For Reduced Mental Health , Oxford University ,