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New Study Sheds Light on the Cause of Severe Inflammatory Bowel Disease

Scientists at Cedars-Sinai have identified a genetic variant that is associated with perianal Crohn's disease. Investigators at Cedars-Sinai have discovered a genetic variant that elevates an individual's likelihood of experiencing perianal Crohn's disease, which is considered to be the most severe ....

United States , Lisas Thomas , Stevenr Brant , Hussein Hamade , Erica Vasiliauskas , Johnd Rioux , Shervin Rabizadeh , Gily Melmed , Davida Ziring , Williama Faubion , Nirupaman Bonthala , Lisaz Greer , Dalin Li , Gregoryj Botwin , Alkaa Potdar , Phillip Fleshner , L Philip Schumm , Marks Silverberg , Michelle Khrom , Ramachandran Murali , Richardh Duerr , Roberts Sandler , Judyh Cho , Emebet Mengesha , Carolj Landers , Ramnikj Xavier ,

Study gives insight into cause of severe infl

Cedars-Sinai investigators have identified a genetic variant that increases people’s risk of developing perianal Crohn’s disease, the most debilitating manifestation of Crohn’s disease. The variant generates changes to DNA that lead to a loss of protein function, which in turn, alters how the body recognizes and handles bacteria, making it less effective at fighting infections. ....

United States , Gregoryj Botwin , Michelle Khrom , Dalin Li , Gaurav Syal , Ramachandran Murali , Lisaz Greer , Perianal Crohn , Alkaa Potdar , Kathrin Michelsen , Emebet Mengesha , Shishir Dube , Andreaj Wolf , Hussein Hamade , Lisas Thomas , Gily Melmed , Erica Vasiliauskas , Carolj Landers , Talin Haritunians , Shaohong Yang , Dermot Mcgovern , Stephan Targan , Marzieh Akhlaghpour , Nirupaman Bonthala , Translational Research , Biomedical Sciences At Cedars ,