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Zika vaccine candidate shows promise in phase I trial


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The Zika virus candidate, Ad26.ZIKV.001, a replication-incompetent human adenovirus serotype 26 (ad26) vector showed promising safety and immunogenicity in a phase I clinical trial. Researchers say the vaccine warrants further development should the need reemerge. The findings are published in Annals of Internal Medicine.
Zika virus (ZIKV) infection is transmitted via mosquito or sexually and may cause severe congenital disease after maternal-fetal transmission. The incidence of Zika virus has declined since the 2015-2016 outbreak, but geographic expansion of the Aedes aegypti mosquito to areas where population-level immunity is low poses a substantial risk for future epidemics. Currently, no vaccine is available. ....

Ellen Kapiteijn , Nadinec Salisch , W Alton Russell , Angela Collom , Danh Barouch , Blood Products Advisory Committee , Leiden University Medical Center , Beth Israel Deaconess Medical Center , Stanford University , Janssen Vaccines , Credible Interval , Dutch Melanoma Treatment Registry , Endocarditis Associated , Illicit Drugs , Medicine Health , Clinical Trials , Environmental Health , Health Care Systems Services , Health Professionals , Infectious Emerging Diseases , Internal Medicine , டப்ல்யூ ஆல்டன் ரஸ்ஸல் , ஏஞ்சலா கோலம் , பெத் இஸ்ரேல் டேப்ககோணேஸ் மருத்துவ மையம் , ஸ்டான்போர்ட் பல்கலைக்கழகம் , ஜான்சன் தடுப்பு மருந்துகள் ,