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In most trial volunteers, a two-dose regimen of a potential vaccine safely produced antibodies that, when transferred to a mouse, successfully neutralized Zika virus cells. This 2003 photo shows a female Aedes albopictus mosquito, the type that can spread the Zika virus, acquiring a blood meal from a human host. (James Gathany/Centers for Disease Control and Prevention via AP) (CN) A vaccine candidate shows promise against the Zika virus, a currently untreatable infection that caught international attention during a 2015-2016 epidemic, and a new study has found that screening blood for the transfusion-transmissible virus may be an inefficient use of resources. ....
URL goes live when the embargo lifts The Zika virus candidate, Ad26.ZIKV.001, a replication-incompetent human adenovirus serotype 26 (ad26) vector showed promising safety and immunogenicity in a phase I clinical trial. Researchers say the vaccine warrants further development should the need reemerge. The findings are published in Annals of Internal Medicine. Zika virus (ZIKV) infection is transmitted via mosquito or sexually and may cause severe congenital disease after maternal-fetal transmission. The incidence of Zika virus has declined since the 2015-2016 outbreak, but geographic expansion of the Aedes aegypti mosquito to areas where population-level immunity is low poses a substantial risk for future epidemics. Currently, no vaccine is available. ....