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New Chinese Neurosurgical Journal Study Reveals Novel Gene Signature for Accurate Prediction of Glioblastoma Prognosis

/PRNewswire/ Early predictions of the prognosis of glioblastoma (GBM) one of most lethal cancers affecting the brain could potentially improve the survival. ....

Tao Jiang , Yi Lu , Capital Medical University , Professor Tao Jiang , Chinese Neurosurgical , Cancer Genome Atlas , Chinese Glioma Genome Atlas , Chinese Neurosurgical Journal , Neurosurgical Journal ,

Function of MIR155HG in glioma at transcriptome level

The purpose of this study was to investigate the function of MIR155HG in glioma at the transcriptome level and relationship with immune infiltration. ....

United States , Eteläuomen Läi , People Hospital Of Nanjing Medical University , Chinese Academy Of Sciences Shanghai , Gold Kit Zymo Research Corp , Cell Bank , Ethics Committee Of The Affiliated Wuxi No , Mini Kit Qiagen Inc , Cell Signaling Technology , Immunosuppressive Properties , Me Association , Chinese Glioma Genome Atlas , Nanjing Medical , Ethics Committee , Nanjing Medical University , Chinese Academy , Premix Ex Taq , Applied Biosystems , Foster City , Bisulfite Amplicon Sequencing , Gold Kit , Zymo Research Corp , Luciferase Reporter , Dual Luciferase Reporter Assay System , Millipore Magna , Was Associated ,

Frontiers | GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma

Background Glioma is a lethal primary tumor of central nervous system. Ferroptosis is a newly identified form of necrotic cell death. Triggering ferroptosis has shown potential to eliminate aggressive tumors. GPX7, a member of glutathione peroxidase family (GPXs), has been described to participate in oxidative stress and tumorigenesis. However, the biological functions of GPX7 in glioma are still unknown. Methods Bioinformatics method was used to assess the prognostic role of GPX7 in glioma. CCK8, wound healing, transwell and cell apoptosis assays were performed to explore the functions of GPX7 in glioma cells. In vivo experiment was also conducted to confirm in vitro findings. Ferroptosis-related assays were carried out to investigate the association between GPX7 and ferroptosis in glioma. Results GPX7 was aberrantly expressed in glioma and higher expression of GPX7 was correlated with adverse outcomes. GPX7 silencing enhanced ferroptosis-related oxidative stress in glioma cells and t ....

United States , United Kingdom , Dunfa Peng , Biochim Biophys Acta , Silva Mcda , Chin Neurosurg , Duttaa Micrornas , Liuy Erastin , Zheng Chen , Extensive Network , Huanhu Hospital Department Of Neurosurgery , Beina Chuanglian Biotechnology Institute , Dojindo Molecular Technology , Sunz Global Research Trends Of Ferroptosis , Cell Bioscience Inc , Committee Of Tianjin Huanhu Hospital , National Natural Science Foundation Of China , Sibeifu Beijing Biotechnology Co , Jackson Immunoresearch Inc , Pathology Department Of Huanhu Hospital , Detection Kit Solarbio Co , Technology Commission , Implications For Cancer Development , Chinese Glioma Genome Atlas , Cancer Genome Atlas , Gene Expression Ominibus ,

Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases

Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases
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Cancer Genome Atlas , Chinese Glioma Genome Atlas , Ivy Glioblastoma Atlas Project ,

Construction of a pyroptosis-related gene prognostic index

A Pyroptosis-Related Gene Prognostic Index Correlated with Survival and Immune Microenvironment in Glioma- Read The Full Article Online ....

Eteläuomen Läi , E Univariate Cox , Univariate Cox , Neurosurgery Department Of Wuhan Union Hospital , Ethics Committee , World Health Organization , Cell Bank , Chinese Academy Of Sciences , Health Organization , Central Brain Tumor Registry , United States , Chinese Glioma Genome Atlas , Cancer Genome Atlas , Glioma Patients , Prognostic Value , Gene Ontology , Kyoto Encyclopedia , Quantitative Real Time Polymerase Chain Reaction , Chinese Academy , Modified Eagle Medium , Premix Ex Taq , Sangon Biotech , Neurosurgery Department , Wuhan Union Hospital , Medical Ethics Committee , Whitneyu Test ,