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An effective strategy for osteosarcoma therapy

The anti-tumor capacities of HANPs with different morphologies and particle sizes against two kinds of OS cells, human OS 143B cells and rat OS UMR106 cells. ....

United States , United Kingdom , Evagreen Supermix , Hanpsn Hanps , Hanpsr Hanps , Hyclone Logan , Abcam Cambridgeshire , Qiagen Hilden , Biosciences Franklin Lakes , Beyotime Institute Of Biotechnology Shanghai , Committee Of Sichuan University , Cell Bioscience Inc China , Solarbio Science Technology Co , Jiancheng Bioengineering Institute , Biorad Laboratories Inc , Cell Bioscience Inc , Chinese Society Of Laboratory Animals , Gempharmatech Co Ltd China , Ribobio Co Ltd , Thermo Fisher Scientific , Modified Eagle Medium , Minimum Essential Medium , Cell Bioscience , Cell Counting , Dojindo Laboratories , Vitro Kit ,

Frontiers | GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma

Background Glioma is a lethal primary tumor of central nervous system. Ferroptosis is a newly identified form of necrotic cell death. Triggering ferroptosis has shown potential to eliminate aggressive tumors. GPX7, a member of glutathione peroxidase family (GPXs), has been described to participate in oxidative stress and tumorigenesis. However, the biological functions of GPX7 in glioma are still unknown. Methods Bioinformatics method was used to assess the prognostic role of GPX7 in glioma. CCK8, wound healing, transwell and cell apoptosis assays were performed to explore the functions of GPX7 in glioma cells. In vivo experiment was also conducted to confirm in vitro findings. Ferroptosis-related assays were carried out to investigate the association between GPX7 and ferroptosis in glioma. Results GPX7 was aberrantly expressed in glioma and higher expression of GPX7 was correlated with adverse outcomes. GPX7 silencing enhanced ferroptosis-related oxidative stress in glioma cells and t ....

United States , United Kingdom , Dunfa Peng , Biochim Biophys Acta , Silva Mcda , Chin Neurosurg , Duttaa Micrornas , Liuy Erastin , Zheng Chen , Extensive Network , Huanhu Hospital Department Of Neurosurgery , Beina Chuanglian Biotechnology Institute , Dojindo Molecular Technology , Sunz Global Research Trends Of Ferroptosis , Cell Bioscience Inc , Committee Of Tianjin Huanhu Hospital , National Natural Science Foundation Of China , Sibeifu Beijing Biotechnology Co , Jackson Immunoresearch Inc , Pathology Department Of Huanhu Hospital , Detection Kit Solarbio Co , Technology Commission , Implications For Cancer Development , Chinese Glioma Genome Atlas , Cancer Genome Atlas , Gene Expression Ominibus ,

Basal epithelial cells in treating prostate cancer

15 Basal epithelial cells are a blood–prostate barrier between luminal cells and basement membrane
16 but are absent in prostate carcinoma.
17–19 Loss of basal epithelial cells is a characteristic of prostate carcinoma
20,21 and one of the diagnostic criteria of prostate cancer,
19 suggesting that some essential connections might exist between basal epithelial cells and prostate cancer cells. So, we put out a question regarding whether basal epithelial cells could suppress migration or invasion of prostate cancer cells when basal epithelial cells are artificially added into a cultured system of prostate cancer cells. Through extensive reading of the medical literature, we found that the effects of basal epithelial cells on prostate cancer cells are still limited. One previous study reported that extracellular matrix of basal epithelial cell inhibited the proliferation of prostate cancer cell LNCaP by secreting TGF-β1. ....

United States , Peprotech Company United States , Gibco Company United States , Cell Bioscience Inc , Cell Co , China University Of Technology School Medicine , Wanlei Company , Research Significance , Proteintech Company Wuhan , Cell Bioscience , South China University , Technology School , Modified Eagle , Gibco Company , Peprotech Company , Proteintech Company , Healing Assays , Conditional Medium , Basal Epithelial , Cells Growing , Beyotime Biotechnology , Normal Basal Epithelial Cells Could Stimulate , Basal Epithelial Cells Might Promote Migration , Previous Studies , ஒன்றுபட்டது மாநிலங்களில் , சீனா பல்கலைக்கழகம் ஆஃப் தொழில்நுட்பம் பள்ளி மருந்து ,