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Targeting T cell iron metabolism may offer a new approach for treating lupus

Targeting iron metabolism in immune system cells may offer a new approach for treating systemic lupus erythematosus (SLE) -; the most common form of the chronic autoimmune disease lupus. ....

United States , Ayaka Sugiura , Evan Krystofiak , W Kimryn Rathmell , Jacob Basham , Emily Henderson , Marissa Young , William Beavers , Dillon Kunkle , Cornelius Vanderbilt , Katherine Gibson Corley , Jeffrey Rathmell , Kelsey Voss , Michelle Ormseth , Eric Skaar , Ernestw Goodpasture , Allison Sewell , Emily Arner , Megan Dickson , Division Of Rheumatology , Vanderbilt Institute For Infection , Vanderbilt University Medical Center , Vanderbilt Center , National Institutes Of Health , Lupus Foundation Of America , Lupus Foundation ,

Cardiac Antigen Identified as Mechanism for Heart Complication

(HEALTH NEWS) Myocarditis is a complication that can occur in cancer patients treated with immune checkpoint inhibitors. Although the adverse event is rare — affecting less than 1% of patients given the immunotherapy — the mortality rate is nearly 50%.
Now, researchers from Vanderbilt-Ingram Cancer Center have identified the mechanism for the deadly heart inflammation.
The researchers discovered that T-cells recognizing the cardiac antigen α-myosin are the mechanism for this . ....

United States , Wouter Meijers , Yueli Zhang , Ayaka Sugiura , Javid Moslehi , Xiaopeng Sun , Warren Tai , Susan Opalenik , Juan Qin , Jeffrey Rathmell , Jamesc Bradford Jr , Abigail Toren , Margaret Axelrod , Jamesp Allison , Brandie Taylor , Elie Tannous , Douglas Johnson , Elizabeth Phillips , Ann Hanna , Kaushik Amancherla , Simon Mallal , P Brent Ferrell , Vanderbilt Ingram Cancer Center , Fund In Melanoma Cancer Research , National Institutes Of Health , Md Anderson Cancer Center ,

Cardiac antigen identified as mechanism for heart complication with immunotherapy-related myocarditis

Cardiac antigen identified as mechanism for heart complication with immunotherapy-related myocarditis
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United States , Yueli Zhang , Ayaka Sugiura , Javid Moslehi , Xiaopeng Sun , Warren Tai , Susan Opalenik , Juan Qin , Jeffrey Rathmell , Jamesc Bradford Jr , Justin Balko , Abigail Toren , Margaret Axelrod , Jamesp Allison , Brandie Taylor , Elie Tannous , Douglas Johnson , Elizabeth Phillips , Ann Hanna , Kaushik Amancherla , Simon Mallal , P Brent Ferrell , Vanderbilt Ingram Cancer Center , Fund In Melanoma Cancer Research , National Institutes Of Health , Md Anderson Cancer Center ,

Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Myocarditis is a complication that can occur in cancer patients treated with immune checkpoint inhibitors. ....

United States , Yueli Zhang , Ayaka Sugiura , Emily Henderson , Javid Moslehi , Xiaopeng Sun , Warren Tai , Susan Opalenik , Juan Qin , Jeffrey Rathmell , Jamesc Bradford Jr , Justin Balko , Abigail Toren , Margaret Axelrod , Jamesp Allison , Brandie Taylor , Elie Tannous , Douglas Johnson , Elizabeth Phillips , Ann Hanna , Kaushik Amancherla , Simon Mallal , P Brent Ferrell , Vanderbilt Ingram Cancer Center , Fund In Melanoma Cancer Research , National Institutes Of Health ,