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New cancer immunotherapy uses engineered T cells to target a common genetic alteration Researchers developed a prototype for a new cancer immunotherapy that uses engineered T cells to target a genetic alteration common among all cancers. The approach, which stimulates an immune response against cells that are missing one gene copy, called loss of heterozygosity (LOH), was developed by researchers at the Ludwig Center, Lustgarten Laboratory and the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center. Genes have two alleles, or copies, with one copy inherited from each parent. Cancer-related genetic alterations commonly involve the loss of one of these gene copies. ....
The tyrosination sensor is the first tubulin nanobody - or sensor - that can be used to study the dynamics of microtubule modifications in living cells. ....
About 6.2 million Americans suffer from heart failure, an incurable disease with a staggering mortality rate - some 40 percent of patients die within five years of diagnosis. Heart failure is one form of heart disease, for which new therapies are desperately needed. ....
Hubble s Latest Image Release Is So Beautiful, It Should Be Illegal Just audacity. The absolute cheek of it. Here you were, just minding your own mundane business, and then Hubble had to come along and remind you that our Universe is jaw-droppingly, mind-blowingly, sickeningly gorgeous.
What you re looking at is a nebula around 4,900 light-years away in the constellation of Gemini. It s named AFGL 5180, and it s part of a vast molecular cloud complex named Gem OB1. Such thick molecular clouds are where stars are born, and AFLG 5180 is no exception. It s spectacularly lit from within by a very young, hot star that s violently disturbing the space around it as it grows, carving out vast cavities in the gas cloud. ....
New approach could treat infertility caused by abnormal GnRH secretion Reports suggest that at least 25% of ovarian disorders are due to dysfunction of the brain mechanism in the hypothalamus that controls the gonadotropin-releasing hormone (GnRH), which is a molecule that governs the reproductive function in men and women by regulating the release of a range of reproductive hormones into the body, particularly gonadotropins, from the pituitary gland, which is located underneath the brain. In a healthy individual, GnRH and gonadotropins are released in pulses, while typically in individuals whose infertility is caused by hypothalmic dysfunction, the GnRH and gonadotropin pulses are supressed. ....