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Scientists Elucidate Molecular Pathway Driving Maladaptive Processes in Heart Failure

Research by scientists at Lewis Katz School of Medicine at Temple University opens door to new therapeutic strategies ....

United States , Daniela Liccardo , Giuseppe Rengo , Anna Maria Lucchese , Erhe Gao , Ines Mucio , Walterj Koch , Alessandro Cannavo , Antonio Rapacciuolo , Andrea Elia , Nicola Ferrara , Istituti Clinici Scientifici Ics Maugeri , Nazareno Paolocci , American Heart Association , National Institutes Of Health , Italian Ministry Of Education , Department Of Pharmacology , Department Of Cardiovascular Sciences , Division Of Cardiology , Research Rita Levi Montalcini , Department Of Translational Medical Sciences , Johns Hopkins University Medical Institutions , Department Of Advanced Biomedical Sciences , Journal Of The American College Cardiology , Katz School Of Medicine , Federico Ii University Of Naples ,

Protein involved in heart development boosts stem cell strategy for heart repair

With age, the human heart gradually loses its ability to repair itself following injury. Damage wrought by injuries such as cardiac ischemia and heart ....

Justin Kurian , Sadia Mohsin , Michael Behanan , Anna Maria Luchesse , Phong Wang , Mohsin Khan , Tao Wang , Walterj Koch , Jih Lee , Antonia Elizabeth Yuko , Vagner Oliveira Carvalho Rigaud , Nicole Kasatkin , Ww Smith Charitable , Professor Of Cardiovascular Sciences , National Institutes Of Health , Lewis Katz School Of Medicine , Department Of Pharmacology , Cardiovascular Research Center , Cardiovascular Research Institute , Metabolic Disease Research , Lewis Katz School , Temple University , Assistant Professor , Cardiovascular Sciences , Translational Medicine , National Institutes ,

Temple, Case Western scientists receive $3 million NIH grant to study pathway behind heart failure

Temple, Case Western scientists receive $3 million NIH grant to study pathway behind heart failure
Like a bad water pump that fails to circulate coolant in a car engine, a failing heart struggles to pump blood through the body, causing symptoms of fatigue, shortness of breath, and swelling in the legs and feet. As heart failure progresses, the heart itself becomes increasingly unable to contract effectively, owing to changes in the molecules that control the heart, particularly a small gaseous molecule called nitric oxide.
Nitric oxide is carried by red blood cells and acts as a signal to relax arteries and increase blood flow to heart tissue. It is also produced within heart cells, where it chemically combines with proteins in a process known as S-nitrosylation. More than 20,000 known S-nitrosylation events turn proteins on or off, including proteins that make up the heart s beta-adrenergic receptor (βAR) system - the system that regulates the fight-or-flight respo ....

Walterj Koch , Jonathans Stamler , Emily Henderson , Sylviak Reitman Family Foundation , University Hospitals In Cleveland , National Institutes Of Health Heart Lung , Department Of Pharmacology , Blood Institute , Case Western Reserve University School Of Medicine , Lewis Katz School , Temple University , Case Western Reserve University School , University Hospitals , National Institutes , Health National Heart Lung , Endowed Chair , Cardiovascular Medicine , Translational Medicine , Family Foundation Distinguished Chair , Cardiovascular Innovation , Transformative Molecular Medicine , Harrington Discovery Institute , University Hospitals Cleveland Medical , Heart Failure , Nitric Oxide , Red Blood Cells ,

Grant gives Temple, Case Western scientists chance to study pathway behind heart failure

Grant gives Temple, Case Western scientists chance to study pathway behind heart failure
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Walterj Koch , Jonathans Stamler , Sylviak Reitman Family Foundation , University Hospitals In Cleveland , National Institutes Of Health Heart Lung , Department Of Pharmacology , Blood Institute , Case Western Reserve University School Of Medicine , Lewis Katz School , Temple University , Case Western Reserve University School , University Hospitals , National Institutes , Health National Heart Lung , Endowed Chair , Cardiovascular Medicine , Translational Medicine , Family Foundation Distinguished Chair , Cardiovascular Innovation , Transformative Molecular Medicine , Harrington Discovery Institute , University Hospitals Cleveland Medical , பல்கலைக்கழகம் மருத்துவமனைகள் இல் கிளீவ்லேண்ட் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் இதயம் நுரையீரல் , துறை ஆஃப் மருந்தியல் , இரத்தம் நிறுவனம் ,

Overexpression of signaling protein in heart associated with poor survival after heart attack

About 6.2 million Americans suffer from heart failure, an incurable disease with a staggering mortality rate - some 40 percent of patients die within five years of diagnosis. Heart failure is one form of heart disease, for which new therapies are desperately needed. ....

United States , Walterj Koch , Emily Henderson , Cardiovascular Research , Lewis Katz School Of Medicine , Department Of Pharmacology , Temple University , Lewis Katz School , Claudio De Lucia , Translational Medicine , Endowed Chair , Cardiovascular Medicine , Heart Attack , Heart Disease , Heart Failure , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , இருதய ஆராய்ச்சி , லெவிஸ் க்யாட்ஸ் பள்ளி ஆஃப் மருந்து , துறை ஆஃப் மருந்தியல் , கோயில் பல்கலைக்கழகம் , லெவிஸ் க்யாட்ஸ் பள்ளி , கிளாடியோ டி லூசியா , மொழிபெயர்ப்பு மருந்து , வழங்கப்பட்டது நாற்காலி , இருதய மருந்து ,