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New approach could treat infertility caused by abnormal GnRH secretion Reports suggest that at least 25% of ovarian disorders are due to dysfunction of the brain mechanism in the hypothalamus that controls the gonadotropin-releasing hormone (GnRH), which is a molecule that governs the reproductive function in men and women by regulating the release of a range of reproductive hormones into the body, particularly gonadotropins, from the pituitary gland, which is located underneath the brain. In a healthy individual, GnRH and gonadotropins are released in pulses, while typically in individuals whose infertility is caused by hypothalmic dysfunction, the GnRH and gonadotropin pulses are supressed. ....