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New approach could treat infertility caused by abnormal GnRH secretion

New approach could treat infertility caused by abnormal GnRH secretion
Reports suggest that at least 25% of ovarian disorders are due to dysfunction of the brain mechanism in the hypothalamus that controls the gonadotropin-releasing hormone (GnRH), which is a molecule that governs the reproductive function in men and women by regulating the release of a range of reproductive hormones into the body, particularly gonadotropins, from the pituitary gland, which is located underneath the brain.
In a healthy individual, GnRH and gonadotropins are released in pulses, while typically in individuals whose infertility is caused by hypothalmic dysfunction, the GnRH and gonadotropin pulses are supressed. ....

Japan General , Hiroko Tsukamura , Emily Henderson , Nagoya University , Proceedings Of The National Academy Sciences , School Of Bioagricultural Science , University Of Tokyo , National Institute , Physiological Sciences , Okazaki City , National Academy , Graduate School , Bioagricultural Science , Professor Hiroko Tsukamura , Kei Ichiro Maeda , Project Leader , Professor Uenoyama , Gene Therapy , Pituitary Gland , Reproductive Hormones , Viral Vector , ஜப்பான் ஜநரல் , எமிலி ஹென்டர்சன் , நாகோயா பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் டோக்கியோ , தேசிய நிறுவனம் ,

Recovery of ovarian function in infertile mammals lacking gonadotropin release

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IMAGE: This study has found that KNDy neurons are key to controlling ovarian function in mammals. These neurons express signalling molecules (peptides) in the brain that stimulate pulses of a hormone.
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Credit: Sho Nakamura
Gonadotropins are any hormones that are released from the anterior pituitary to stimulate the gonads, or sex glands, to carry out their reproductive functions. The gonadotropin-releasing hormone (GnRH) is therefore fundamental for mammalian reproduction. In a healthy reproductive system GnRH is produced by the brain in pulses. Reports suggest that at least 25% of ovarian disorders are due to dysfunction of the brain mechanism controlling the release of gonadotropins, which is a kind of reproductive disorder associated with the hypothalamus. ....

Japan General , Hiroko Tsukamura , Mayuko Nagae , Bio Research At Nagoya University , Program Of Transformative Chem , School Of Bioagricultural Science , Technology Research Promotion Program For Agriculture , Nagoya University , Proceedings Of The National Academy Sciences , University Of Tokyo , Japan Society For The Promotion Of Science , Graduate School , Bioagricultural Science , National Institute , Physiological Sciences , Okazaki City , National Academy , Kei Ichiro Maeda , Associate Professor Uenoyama , Natl Acad Sci United , Japan Society , Cooperative Study Program , Graduate Program , Transformative Chem Bio Research , Professor Kei Ichiro Maeda , Basic Research Activities ,