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New substance suppresses the growth of harmful bacteria that cause periodontitis

New substance suppresses the growth of harmful bacteria that cause periodontitis
Targeted, efficient and with few side effects: A new method for combating periodontitis could render the use of broad-spectrum antibiotics superfluous. It was developed and tested for the first time by a team from Martin Luther University Halle-Wittenberg (MLU), the Fraunhofer Institute for Cell Therapy and Immunology IZI and Periotrap Pharmaceuticals GmbH. The aim is to neutralize only bacteria that cause periodontitis while sparing harmless bacteria. The study appeared in the
Journal of Biological Chemistry.
Periodontitis is a common bacterial inflammation of the gums. According to the World Health Organization WHO Oral Health Study, almost 10 percent of the global population are affected with a severe form of the disease, which can lead to tooth loss as well as increasing the risk of other diseases, such as Alzheimer s and cardiovascular disease. Until now, treatment has mainly involve ....

Miltont Stubbs , Mirko Buchholz , Emily Henderson , Periotrap Pharmaceuticals Gmb , Martin Luther University Halle Wittenberg , Jagiellonian University In Krakow , World Health Organization , Periotrap Pharmaceuticals , Fraunhofer Institute For Cell Therapy , University Of Bern , Department Of Drug Design , Oral Health Study , University Of Louisville , Fraunhofer Institute , Cell Therapy , Health Study , Professor Milton , Drug Design , Target Validation , Dental Medicine , Jagiellonian University , United States , மிற்கோ புச்சோல்ஸ் , எமிலி ஹென்டர்சன் , மார்டின் லூதர் பல்கலைக்கழகம் ஹால் விட்டன்பெர்க் , உலகம் ஆரோக்கியம் ஆர்கநைஸேஶந் ,

Novel host-viral-microbiome interactions during COVID-19 may determine outcome

Novel host-viral-microbiome interactions during COVID-19 may determine outcome
The current pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been spreading rapidly for over a year. Though primarily a respiratory illness, its manifestations are often protean and may be life-threatening.
A new preprint on the
medRxiv server discusses how the underlying disease mechanisms are regulated such that the local or mucosal immune response is distinct from the systemic response.
Viral suppression of innate but not adaptive immunity
The initial infection of epithelial cells in the upper respiratory tract, via the angiotensin-converting enzyme 2 (ACE2), triggers early innate defenses that prevent replicative infection and progressive disease. ....

Liji Thomas , Andrii Vodolazhskyi Shutterstock , Andrii Vodolazhskyi , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Cell Cycle , Cell Signaling , Corona Virus , Immune Response , Immune System , Respiratory Illness , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , செல் மிதிவண்டி , செல் சமிக்ஞை , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , நோய் எதிர்ப்பு சக்தி அமைப்பு , வளர்சிதை மாற்றம் , சர்வதேச பரவல் , சுவாச உடல் நலமின்மை , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Study reveals a small molecule inhibits SARS-CoV-2 infection in cells

Researchers found a small molecule that inhibits different virus proteins and significantly reduces infection in cells. Combined with the antiviral remdesivir, its potency increases significantly, suggesting it may be a potential antiviral candidate for the treatment of COVID-19. ....

Lakshmi Supriya , Drug Administration , Phd Mar , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Cell Line , Corona Virus , In Vitro , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , லட்சுமி சுப்ரியா , ஃப்ட் மார் , செல் வரி , கொரோனா வைரஸ் , இல் விட்ரோ , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Scientists reprogram a common bacterium to make designer sugar-based drug

Scientists reprogram a common bacterium to make designer sugar-based drug
Envisioning an animal-free drug supply, scientists have -; for the first time -; reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals. Published today in
Nature Communications, the researchers modified
E. coli to produce chondroitin sulfate, a drug best known as a dietary supplement to treat arthritis that is currently sourced from cow trachea.
Genetically engineered
E. coli is used to make a long list of medicinal proteins, but it took years to coax the bacteria into producing even the simplest in this class of linked sugar molecules -; called sulfated glycosaminoglycans -;that are often used as drugs and nutraceuticals.. ....

Jonathan Dordick , Deepak Vashishth , Robert Linhardt , Mattheos Koffas , Emily Henderson , Nature Communications , Rensselaer Polytechnic Institute , Rensselaer Polytechnic , E Coli , தீபக் வஷிஷ்ட் , ராபர்ட் லின்ஹார்ட் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , ரென்சீலர் பாலிடெக்நிக் நிறுவனம் , ரென்சீலர் பாலிடெக்நிக் , ஏ கோலி ,

Concerning mutation in New York SARS-CoV-2 should be monitored, warn researchers

Researchers at the New York State Department of Health in the United States have said concerning mutations within the B.1.526 lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has recently become prevalent in New York State warrant further monitoring. ....

New York , United States , South Africa , Erica Lasek Nesselquist , Sally Robertson , York State Department Of Health , New York State Department , New York State , United Kingdom , Graphics System , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , Public Health , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , சாலி ராபர்ட்சன் , யார்க் நிலை துறை ஆஃப் ஆரோக்கியம் , புதியது யார்க் நிலை துறை , புதியது யார்க் நிலை , ஒன்றுபட்டது கிஂக்டம் ,