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UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth


Significance
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and is one of the most deadly cancer types, with a 5-y survival rate below 10%. One reason for this high mortality rate is that PDAC cells have an enhanced ability to survive and proliferate despite existing in nutrient-deprived environments. Understanding the metabolic rewiring that enables nutrient scavenging and rapid metabolic processing of PDAC cells can provide new strategies to develop effective treatment options for this intractable disease. In this study, convergent findings reveal that UGP2 has a central role in the growth and metabolism of PDAC cells through the regulation of glycogen synthesis and protein N-glycosylation, highlighting therapeutic possibilities for this deadly cancer. ....

Invitrogen Nupage , Matrigel Corning , Fisher Powergen , Blasticidin Fisher , University Of California San Francisco , Dependency Map , Atlanta Biologicals , Glycogen Assay Kit , Precision Metabolomics , California San Francisco , Institutional Animal Care , Use Committee , Santa Cruz Biotechnology , Cell Signaling , Novus Biologicals , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் பிரான்சிஸ்கோ , அட்லாண்டா உயிரியல் , கலிஃபோர்னியா சான் பிரான்சிஸ்கோ , நிறுவன விலங்கு பராமரிப்பு , பயன்பாடு குழு , சாந்தா குரூஸ் உயிரி தொழில்நுட்பவியல் , செல் சமிக்ஞை , புதிய உயிரியல் ,

Developer deep dive: Designing proteins and reagents for cell and gene therapy research on SelectScience


23 Aug 2021
Recombinant proteins require strict quality control, as quality issues affect the reliability of the intended downstream application. Cell and gene therapy research in particular demands a higher quality of protein that adheres to strict quality control and has comprehensive validation.
In this exclusive SelectScience
® webinar, Dr. Deborah Moore-Lai, Director of Protein Development at Abcam, will introduce a new range of premium bioactive proteins. During the session, Moore-Lai will be detailing Abcam’s manufacturing workflow, as well as outlining the company’s mission to support scientists in achieving their goals in cell and gene therapy research and other research areas. ....

Deborah Moore Lai , Cell Signaling Technology , Merck Research Laboratories , Protein Development , Protein Development At Abcam , Proteins Initiative , Antibody Production , Cell Signaling , செல் சமிக்ஞை தொழில்நுட்பம் , மெர்க் ஆராய்ச்சி ஆய்வகங்கள் , ப்ரோடீந் வளர்ச்சி , ஆன்டிபாடி ப்ரொடக்ஶந் , செல் சமிக்ஞை ,

Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration