25 Nevertheless, the reports of ITGA9 in melanoma are few. The objective of our present study was to explore the role of HOXA11-AS in melanoma and the regulatory mechanism among HOXA11-AS, miR-152-3p and ITGA9 in cellular processes, intending to promote the understanding of the molecular pathogenesis in melanoma. Materials and Methods Ethic Statement For clinical human samples, our study was performed after obtaining ratification from the Ethics Committee of The First Affiliated Hospital of Zhengzhou University. The research has been carried out in accordance with the World Medical Association Declaration of Helsinki, and that all subjects provided written informed consent. The animal experiment in this research was authorized by the Experimental Animal Ethics Committee of The First Affiliated Hospital of Zhengzhou University. Animal studies were performed in compliance with the ARRIVE guidelines and the Basel Declaration. All animals received humane care according to the National Institutes of Health (USA) guidelines.