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Gelatin hydrogel can be used in trophoblast spheroid motility assays, shows study Trophoblast cells, which surround the developing blastocyst in early pregnancy, play an important role in implantation in the uterine wall. A new multidimensional model of trophoblast motility that utilizes a functionalized hydrogel is described in the peer-reviewed journal Tissue Engineering, Part A. This valuable new tool, based on a methacrylamide-functionalized gelatin hydrogel, can be used for three-dimensional trophoblast spheroid motility assays. It can resolve quantifiable differences in outgrowth area and viability in the presence of a known invasion promoter and a known invasion inhibitor. Implantation involves a highly coordinated molecular dialogue between endometrial cells and trophoblast cells. Developing a deeper understanding of the biological mechanisms surrounding implantation may provide critical insights into pregnancy and pregnancy disorders.

United statesUniversity of illinoisBrendan harleyJohnp fisherEmily hendersonTissue engineering coUniversity of marylandFischell family distinguished professor departmentTissue engineeringTissue engineering co editor in chief johnFischell family distinguished professorDepartment chairEngineering complex tissuesஒன்றுபட்டது மாநிலங்களில்பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ்பிரெண்டன் ஹார்லி