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Gene Editing Expands to New Types of Immune Cells
Gladstone researchers fine-tuned CRISPR-Cas9 genome editing to work on human immune cells called monocytes
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SAN FRANCISCO, May 11, 2021 /PRNewswire/ In the decade since the advent of CRISPR-Cas9 gene editing, researchers have used the technology to delete or change genes in a growing number of cell types. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) have added human monocytes white blood cells that play key roles in the immune system to that list.
A team of scientists at Gladstone Institutes and UC San Francisco led by Alex Marson (left) and Nevan Krogan (right) fine-tuned CRISPR-Cas9 genome editing to help understand how the human immune system fights viruses and microbes.
New method helps map the specialized diversity and spatial location of cells within a tissue or tumor
Not all cancer cells within a tumor are created equal; nor do all immune cells (or all liver or brain cells) in your body have the same job. Much of their function depends on their location.
Now, researchers at Gladstone Institutes, UC San Francisco (UCSF), and UC Berkeley have developed a more efficient method than ever before to simultaneously map the specialized diversity and spatial location of individual cells within a tissue or a tumor.
The technique, called XYZeq, was described online this week in the journal
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SAN FRANCISCO, CA April 21, 2021 Not all cancer cells within a tumor are created equal; nor do all immune cells (or all liver or brain cells) in your body have the same job. Much of their function depends on their location. Now, researchers at Gladstone Institutes, UC San Francisco (UCSF), and UC Berkeley have developed a more efficient method than ever before to simultaneously map the specialized diversity and spatial location of individual cells within a tissue or a tumor.
The technique, called XYZeq, was described online this week in the journal
Science Advances. It involves segmenting a tissue into a microscopic grid before analyzing RNA from intact cells in each square of the grid, in order to gain a clear understanding of how each particular cell is functioning within its spatial location. This offers new insight into the organization of tissues and the interplay between different cell types during disease, including in cancers.
XYZeq: A better map of cell diversity
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