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Giving Immunotherapy Cells Resilience to Pass the Stress Test

T cells used in immunotherapy treatments can get exhausted and shut down by fighting cancer cells and tumors. Using a CRISPR-based edit on these cells’ genomes, researchers at UCSF and Gladstone Institutes have rendered the therapeutic cells more resilient against tumors.

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A Cellular Engineering Breakthrough: High-Yield CRISPR Without Viral Vectors

/PRNewswire/ A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications..

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A Cellular Engineering Breakthrough: High-Yield CRISPR Without Viral Vectors

A Cellular Engineering Breakthrough: High-Yield CRISPR Without Viral Vectors
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United statesSan franciscoDavidn nguyenChan zuckerberg biohubShane vedovaDavid wuYan yi chienZhong liCarlose castroTheodorel rothAlexis talbotJing yi chungEric shifrutJeffrey wolfMuradr mamedovJonathan esensten

Giving Immunotherapy Cells Resilience to Pass Stress Test

Giving Immunotherapy Cells Resilience to Pass Stress Test
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United statesSan franciscoNupura kaleBence danielShane vedovaJulia belkShannon langeYan yi chenMarie luetke everslohWilliama nybergTheodorel rothZhongmei liEric shifrutScott koganBrooke prinzingDalia haydar

Gene Editing Expands to New Types of Immune Cells

Gene Editing Expands to New Types of Immune Cells Gladstone researchers fine-tuned CRISPR-Cas9 genome editing to work on human immune cells called monocytes News provided by Share this article Share this article SAN FRANCISCO, May 11, 2021 /PRNewswire/ In the decade since the advent of CRISPR-Cas9 gene editing, researchers have used the technology to delete or change genes in a growing number of cell types. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) have added human monocytes white blood cells that play key roles in the immune system to that list. A team of scientists at Gladstone Institutes and UC San Francisco led by Alex Marson (left) and Nevan Krogan (right) fine-tuned CRISPR-Cas9 genome editing to help understand how the human immune system fights viruses and microbes.

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