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CRISPR-based mapping uncovers switches for immune genes central to health

Healthy T cells are the foundation of a balanced immune system. They can spring into action to fight off infections or cancer, but keep from becoming so activated that they hurt the very cells they re meant to protect, as is the case in autoimmune diseases.

Racing modified cells against each other in humans may be the next step in gene therapies

The next evolution of gene therapies may involve pitting T cells with different modifications against one another in a “race” inside a human to determine which edits produce the best results against a tumor, an expert panel predicted. Researchers across the globe have discovered dozens of genes that could be targeted to make T cells more durable and effective in tumor

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