New method helps map the specialized diversity and spatial location of cells within a tissue or tumor
Not all cancer cells within a tumor are created equal; nor do all immune cells (or all liver or brain cells) in your body have the same job. Much of their function depends on their location.
Now, researchers at Gladstone Institutes, UC San Francisco (UCSF), and UC Berkeley have developed a more efficient method than ever before to simultaneously map the specialized diversity and spatial location of individual cells within a tissue or a tumor.
The technique, called XYZeq, was described online this week in the journal
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SAN FRANCISCO, CA April 21, 2021 Not all cancer cells within a tumor are created equal; nor do all immune cells (or all liver or brain cells) in your body have the same job. Much of their function depends on their location. Now, researchers at Gladstone Institutes, UC San Francisco (UCSF), and UC Berkeley have developed a more efficient method than ever before to simultaneously map the specialized diversity and spatial location of individual cells within a tissue or a tumor.
The technique, called XYZeq, was described online this week in the journal
Science Advances. It involves segmenting a tissue into a microscopic grid before analyzing RNA from intact cells in each square of the grid, in order to gain a clear understanding of how each particular cell is functioning within its spatial location. This offers new insight into the organization of tissues and the interplay between different cell types during disease, including in cancers.
XYZeq: A better map of cell diversity miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
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IMAGE: A team led by Nevan Krogan at Gladstone and UCSF has demonstrated that a large-scale and systematic genetic approach can indeed yield reliable and detailed information on the structure of. view more
Credit: QBI, UCSF
SAN FRANCISCO, CA December 10, 2020 One of biologists most vexing tasks is figuring out how proteins, the molecules that carry the brunt of a cell s work, do their job. Each protein has a variety of knobs, folds, and clefts on its surface that dictate what it can do. Scientists can visualize these features fairly easily on individual proteins. But proteins don t act alone, and scientists also need to know the shape and composition the structure, as they call it of the complexes that proteins form when working together.