Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia.

Related Keywords

Houston ,Texas ,United States ,Baylor College Of Medicine ,Jun Li ,Wei Li ,Xing Fang ,Lingyong Li ,Zeinab Mehsein ,Changqun Yao ,Kimberley Tolias ,National Institutes Of Health ,Department Of Anesthesiology ,Mission Connect ,Department Of Neurobiology ,Marnixe Heersink School Of Medicine ,University Of Alabama At Birmingham ,Baylor College ,Associate Professor ,Clinical Investigation ,Perioperative Medicine ,National Institutes ,Morphine ,Eurons ,Pectin ,Anesthesiology ,Rain ,Hronic ,Chronic Pain ,Nzyme ,Hyperalgesia ,Knockout ,Medicine ,Ouse Model ,Euron ,Neuropathic Pain ,Opioids ,Pain Management ,Perioperative ,Mh ,Eceptor ,Research ,Pine ,