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Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia. ....

United States , Baylor College Of Medicine , Jun Li , Wei Li , Xing Fang , Lingyong Li , Zeinab Mehsein , Changqun Yao , Kimberley Tolias , National Institutes Of Health , Department Of Anesthesiology , Mission Connect , Department Of Neurobiology , Marnixe Heersink School Of Medicine , University Of Alabama At Birmingham , Baylor College , Associate Professor , Clinical Investigation , Perioperative Medicine , National Institutes , Chronic Pain , Ouse Model , Neuropathic Pain , Pain Management ,

Morphine tolerance found to result from Tiam1-mediated maladaptive plasticity in spinal neurons

Morphine tolerance found to result from Tiam1-mediated maladaptive plasticity in spinal neurons
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United States , Baylor College Of Medicine , Changqun Yao , Lingyong Li , Kimberley Tolias , Department Of Anesthesiology , University Of Alabama At Birmingham , Public Domain , Baylor College , Clinical Investigationstudy , Clinical Investigation ,

Neuropathic pain study uncovers pathophysiological mechanism and promising therapeutic target

Neuropathic pain -; abnormal hypersensitivity to stimuli -; is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV. ....

Baylor College Of Medicine , United States , Emily Henderson , Lingyong Li , Kimberley Tolias , Associate Professor , Birmingham Department , Baylor College , Neuropathic Pain , Chronic Pain , Ouse Model ,