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Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia. ....

United States , Baylor College Of Medicine , Jun Li , Wei Li , Xing Fang , Lingyong Li , Zeinab Mehsein , Changqun Yao , Kimberley Tolias , National Institutes Of Health , Department Of Anesthesiology , Mission Connect , Department Of Neurobiology , Marnixe Heersink School Of Medicine , University Of Alabama At Birmingham , Baylor College , Associate Professor , Clinical Investigation , Perioperative Medicine , National Institutes , Chronic Pain , Ouse Model , Neuropathic Pain , Pain Management ,