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Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia. ....

United States , Baylor College Of Medicine , Jun Li , Wei Li , Xing Fang , Lingyong Li , Zeinab Mehsein , Changqun Yao , Kimberley Tolias , National Institutes Of Health , Department Of Anesthesiology , Mission Connect , Department Of Neurobiology , Marnixe Heersink School Of Medicine , University Of Alabama At Birmingham , Baylor College , Associate Professor , Clinical Investigation , Perioperative Medicine , National Institutes , Chronic Pain , Ouse Model , Neuropathic Pain , Pain Management ,

Morphine tolerance results from Tiam1-mediated maladaptive plasticity in spinal neurons

Understanding the mechanisms underlying tolerance and hyperalgesia is essential to enhance morphine’s utility in chronic pain management. Understanding the mechanisms underlying tolerance and hyperalgesia is essential to. ....

United States , Baylor College Of Medicine , Kimberley Tolias , Jun Li , Wei Li , Xing Fang , Lexi Coonli , Changqun Yao , Lingyong Li , Zeinab Mehsein , National Institutes Of Health , Mission Connect , Department Of Neurobiology , University Of Alabama At Birmingham , Marnixe Heersink School Of Medicine , Department Of Anesthesiology , Baylor College , Clinical Investigation , Perioperative Medicine , National Institutes , Health Care , Economic Development ,

Morphine Tolerance Linked to Tiam1-Mediated Neuron Changes

Morphine Tolerance Linked to Tiam1-Mediated Neuron Changes
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United States , Baylor College Of Medicine , Changqun Yao , Zeinab Mehsein , Wei Li , Jun Li , Xing Fang , Kimberley Tolias , Lingyong Li , University Of Alabama At Birmingham , Mission Connect , Department Of Anesthesiology , Department Of Neurobiology , National Institutes Of Health , Marnixe Heersink School Of Medicine , Baylor College , Clinical Investigation , Perioperative Medicine , National Institutes ,

Morphine tolerance found to result from Tiam1-mediated maladaptive plasticity in spinal neurons

Morphine tolerance found to result from Tiam1-mediated maladaptive plasticity in spinal neurons
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

United States , Baylor College Of Medicine , Changqun Yao , Lingyong Li , Kimberley Tolias , Department Of Anesthesiology , University Of Alabama At Birmingham , Public Domain , Baylor College , Clinical Investigationstudy , Clinical Investigation ,

Gene Tiam1 Drives Onset of Chronic Neuropathic Pain

Gene Tiam1 Drives Onset of Chronic Neuropathic Pain
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United States , Baylor College Of Medicine , Xing Fang , Lingyong Li , Changqun Yao , Guanxing Chen , Kimberleyf Tolias , Yungang Lu , Jianghan University , Department Of Defense , University Of Texas Md Anderson Cancer Center , University Of Alabama At Birmingham , University Of Alabama , National Institutes Of Health , Mission Connect , Baylor College , Ali Bin Saifullah , National Institutes ,