First of Its Kind Cystic Fibrosis Gene Expression Atlas Reveals Altered Airway Cells
May 10, 2021
Healthy airways (left) show well-defined layers of ciliated cells (green) and basal stem cells (red). In airways affected by cystic fibrosis (right), the layers are disrupted, and scientists identified a transitioning cell type that combines properties of both stem cells and ciliated cells (red and green in the same cell) [Source: UCLA Broad Stem Cell Research Center/Nature Medicine].
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A multi-institute consortium study reports single-cell transcriptomics data that compares cells lining the airways of cystic fibrosis (CF) patients undergoing transplantation for terminal lung disease with that of previously healthy lung donors in a first-of-its-kind molecular atlas.