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Cedars-Sinai receives $11 99 million from CIRM to launch ALS Clinical Trial

Cedars-Sinai receives $11.99 million from CIRM to launch ALS clinical trial Cedars-Sinai has been awarded $11.99 million by California s stem cell agency to launch a clinical trial testing a potential gene and stem cell therapy for amyotrophic lateral sclerosis (ALS). ALS, or Lou Gehrig s disease, is a progressive neurodegenerative disease that damages nerve cells known as motor neurons in the brain and spinal cord that control voluntary muscle movement. It affects an estimated 16,000 people in the U.S. and is usually fatal within five years of diagnosis. There is no known cure and only limited treatments that may slow progression in a subset of patients.

First of Its Kind Cystic Fibrosis Gene Expression Atlas Reveals Altered Airway Cells

First of Its Kind Cystic Fibrosis Gene Expression Atlas Reveals Altered Airway Cells May 10, 2021 Healthy airways (left) show well-defined layers of ciliated cells (green) and basal stem cells (red). In airways affected by cystic fibrosis (right), the layers are disrupted, and scientists identified a transitioning cell type that combines properties of both stem cells and ciliated cells (red and green in the same cell) [Source: UCLA Broad Stem Cell Research Center/Nature Medicine]. Share A multi-institute consortium study reports single-cell transcriptomics data that compares cells lining the airways of cystic fibrosis (CF) patients undergoing transplantation for terminal lung disease with that of previously healthy lung donors in a first-of-its-kind molecular atlas.

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