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First of Its Kind Cystic Fibrosis Gene Expression Atlas Reveals Altered Airway Cells
May 10, 2021
Healthy airways (left) show well-defined layers of ciliated cells (green) and basal stem cells (red). In airways affected by cystic fibrosis (right), the layers are disrupted, and scientists identified a transitioning cell type that combines properties of both stem cells and ciliated cells (red and green in the same cell) [Source: UCLA Broad Stem Cell Research Center/Nature Medicine].
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A multi-institute consortium study reports single-cell transcriptomics data that compares cells lining the airways of cystic fibrosis (CF) patients undergoing transplantation for terminal lung disease with that of previously healthy lung donors in a first-of-its-kind molecular atlas.
Nature Medicine
Healthy airways (left) show well-defined layers of ciliated cells (green) and basal stem cells (red). In airways affected by cystic fibrosis (right), the layers are disrupted, and scientists identified a transitioning cell type that combines properties of both stem cells and ciliated cells (red and green in the same cell).
A team of researchers from UCLA, Cedars-Sinai and the Cystic Fibrosis Foundation has developed a first-of-its-kind molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis.
The catalog, described today in the journal Nature Medicine, reveals new subtypes of cells and illustrates how the disease changes the cellular makeup of the airways. The findings could help scientists in their search for specific cell types that represent prime targets for genetic and cell therapies for cystic fibrosis.
The Schools of Medicine at Yale and University of Pittsburgh are joining forces with Three Lakes Foundation to accelerate a cure for pulmonary fibrosis
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CHICAGO, March 17, 2021 /PRNewswire/ Three Lakes Foundation (TLF) has announced that it has selected Yale University School of Medicine and the University of Pittsburgh School of Medicine to join the
Three Lakes Consortium for Pulmonary Fibrosis (TLC4PF). Together, they will focus on advancing disease understanding with the goal to accelerate new treatments and curing this devastating lung condition.
Naftali Kaminski, MD, Yale School of Medicine and Melanie Königshoff, MD, University of Pittsburgh School of Medicine are joining forces with Three Lakes Foundation