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First of Its Kind Cystic Fibrosis Gene Expression Atlas Reveals Altered Airway Cells

First of Its Kind Cystic Fibrosis Gene Expression Atlas Reveals Altered Airway Cells
May 10, 2021
Healthy airways (left) show well-defined layers of ciliated cells (green) and basal stem cells (red). In airways affected by cystic fibrosis (right), the layers are disrupted, and scientists identified a transitioning cell type that combines properties of both stem cells and ciliated cells (red and green in the same cell) [Source: UCLA Broad Stem Cell Research Center/Nature Medicine].
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A multi-institute consortium study reports single-cell transcriptomics data that compares cells lining the airways of cystic fibrosis (CF) patients undergoing transplantation for terminal lung disease with that of previously healthy lung donors in a first-of-its-kind molecular atlas. ....

United States , John Mahoney , Brigitte Gomperts , Barry Stripp , Kathrin Plath , Cystic Fibrosis Foundation Therapeutics Lab , Broad Stem Cell Research Center , David Geffen School Of Medicine , University Of Utah , Sinai Board Of Governors Regenerative Medicine Institute , Nature Medicine , Phd Brigitte Gomperts , Stem Cell Research Center , David Geffen School , Molecular Physiology Section , American Physiological Society , Cedars Sinai Board , Governors Regenerative Medicine Institute , ஒன்றுபட்டது மாநிலங்களில் , ஜான் மஹோனி , சிஸ்டிக் ஃபைப்ரோஸிஸ் அடித்தளம் சிகிச்சை ஆய்வகம் , பரந்த தண்டு செல் ஆராய்ச்சி மையம் , டேவிட் கெஃப்ஃபெந் பள்ளி ஆஃப் மருந்து , பல்கலைக்கழகம் ஆஃப் உட்டா , சினை பலகை ஆஃப் கவர்னர்கள் மீளுருவாக்கம் மருந்து நிறுவனம் , இயற்கை மருந்து ,

Molecular analysis identifies key differences in lungs of cystic fibrosis patients

Nature Medicine
Healthy airways (left) show well-defined layers of ciliated cells (green) and basal stem cells (red). In airways affected by cystic fibrosis (right), the layers are disrupted, and scientists identified a transitioning cell type that combines properties of both stem cells and ciliated cells (red and green in the same cell).
A team of researchers from UCLA, Cedars-Sinai and the Cystic Fibrosis Foundation has developed a first-of-its-kind molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis.
The catalog, described today in the journal Nature Medicine, reveals new subtypes of cells and illustrates how the disease changes the cellular makeup of the airways. The findings could help scientists in their search for specific cell types that represent prime targets for genetic and cell therapies for cystic fibrosis. ....

Brigitte Gomperts , Barry Stripp , Kathrin Plath , John Jed Mahoney , Gianni Carraro , Justin Langerman , National Cancer Institute , Cystic Fibrosis Foundation , Tumor Cell Biology Training Program , Sinai Board Of Governors Regenerative Medicine Institute , Parkerb Francis Foundation Fellowship , National Heart , Blood Institute , Edythe Broad Center , Stem Cell Research , Cystic Fibrosis Foundation Therapeutics Lab , Broad Stem Cell Research Center , National Institutes Of Health , David Geffen School Of Medicine , Wm Keck Foundation , Disease Research Program , Cystic Fibrosis Foundation Epithelial Stem Cell Consortium , Howard Hughes Medical Institute , Nature Medicine , Regenerative Medicine , Cystic Fibrosis Foundation Therapeutics ,

Minority Patients Miss Out On Life-Saving Cystic Fibrosis Drugs Due to Genetic Test Limitations

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Minority Patients Miss Out On Life-Saving Cystic Fibrosis Drugs Due to Genetic Test Limitations
There are many new drugs to treat cystic fibrosis, but non-white patients are effectively disqualified from receiving the latest precision medicines, accord to a new study. These drugs were approved by the U.S. Food and Drug Administration (FDA) for people with specific mutations, but non-white patients are more likely to carry different CF mutations. Because these other mutations aren’t included in genetic tests to qualify for the drugs, doctors cannot prescribe these new treatments for non-white patients, and insurance carriers won’t cover the cost. ....

Puerto Rico , United States , Puerto Rican , Esteban Burchard , Susannaa Mccolley , Meghan Mcgarry , Northwestern University Clinical , Cystic Fibrosis Foundation Therapeutics Lab , Drug Administration , Cystic Fibrosis Foundation , Northwestern University Feinberg School Of Medicine , Translational Sciences Institute , Blood Institute , National Heart , Pediatric Pulmonology , Northwestern University , Feinberg School , Cystic Fibrosis Foundation Therapeutics , Cystic Fibrosis , ப்வெர்டோ ரிக்கோ , ஒன்றுபட்டது மாநிலங்களில் , ப்வெர்டோ ரிக்கன் , எஸ்டெபாந் புர்ச்சார்ட் , மேகன் மக்யாரீ , வடமேற்கு பல்கலைக்கழகம் மருத்துவ , சிஸ்டிக் ஃபைப்ரோஸிஸ் அடித்தளம் சிகிச்சை ஆய்வகம் ,