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Obituary: Timothy John Edward Paquette, 32, of Orange patch.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from patch.com Daily Mail and Mail on Sunday newspapers.
4:58 PM UTC share-square-1975362 A special collection of activities has been coordinated by Major League Baseball, its Clubs and the Lou Gehrig Day Committee to celebrate the inaugural “Lou Gehrig Day” on Wednesday, June 2nd. These efforts include special moments at Major League ballparks and a series of fundraising efforts aimed at supporting charitable organizations, notably the Expanded Access Protocol (EAP) program at the Sean M. Healey and AMG Center for ALS at Massachusetts General Hospital (Healey Center for ALS). “4th INNING” VIDEO FEATURE STARRING STEVE GLEASON ALS Advocate Steve Gleason will be featured in a special ballpark moment highlighted during the 4th inning (or pregame in some ballparks) of all Lou Gehrig Day games. During this moment, a video created especially for Lou Gehrig Day will be shown to offer a glimpse into Gleason’s own voice as he recites a part of Gehrig’s famous “Luckiest Man” retirement speech. This opportunity ....
E-Mail Newly published papers further elucidate the mechanisms underlying pridopidine s neuroprotective properties through activation of the Sigma-1 Receptor (S1R). Pridopidine enhances mitochondrial function and reduces mHTT-induced ER stress, which are impaired in HD, mediated by the S1R. Three new peer-reviewed publications highlight pridopidine s therapeutic potential and provide data supporting the role of the S1R in neurodegenerative diseases Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, today announces the publication of three peer-reviewed journal articles, highlighting key aspects of the mechanism of action of its lead asset, pridopidine, and the importance of S1R activation as a mechanism to attenuate biological features of neurodegenerative diseases. ....