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Cleveland Clinic receives $6.7 million NIH grant to study high-intensity exercise as Alzheimer's prevention

Cleveland Clinic receives $6.7 million NIH grant to study high-intensity exercise as Alzheimer s prevention
Contributed photo
With the support of a $6.7 million NIH grant, Cleveland Clinic researchers will evaluate whether high-intensity exercise can prevent the development of Alzheimer’s disease.
Cleveland Clinic has received a $6.7 million grant for a five-year study assessing the effect of home-based indoor cycling in slowing disease progression in healthy older people at high genetic risk for developing Alzheimer s disease, according to a news release.
The grant, from the National Institutes of Health, supports a randomized control trial exploring whether a long-term exercise intervention program can alter progression of late-onset Alzheimer s disease in sedentary, high-risk individuals. If successful, the trial has the potential to provide a scalable, low-cost intervention that could substantially reduce health care costs by modifying the disease trajectory. ....

Jay Alberts , Stephen Rao , National Institutes Of Health , Cleveland Clinic Neurological Institute , Cleveland Clinic Lou Ruvo Center , Brain Health , Health Inc , Cleveland Clinic , National Institutes , Lerner Research Institute , Neurological Institute , ஜெய் ஆல்பர்ட்ஸ் , ஸ்டீபன் ராவ் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , கிளீவ்லேண்ட் சிகிச்சையகம் நரம்பியல் நிறுவனம் , கிளீவ்லேண்ட் சிகிச்சையகம் லூ ருவோ மையம் , மூளை ஆரோக்கியம் , ஆரோக்கியம் இன்க் , கிளீவ்லேண்ட் சிகிச்சையகம் , தேசிய நிறுவனங்கள் , லெர்னர் ஆராய்ச்சி நிறுவனம் , நரம்பியல் நிறுவனம் ,

Centerpiece of Cleveland's New Innovation District Will be Virus Research

Cleveland Clinic
Cleveland Clinic will invest $300 million in building a Global Center for Pathogen Research and Human Health at its main campus as part of the Cleveland Innovation District announced Monday.
Cleveland will be the home to Ohio’s second “innovation district,” a health-care focused, $565 million job-creation partnership with the city s three major hospitals and Case Western Reserve and Cleveland State universities.
Gov. Mike DeWine said the state expects the Cleveland Innovation District to spark 10,000 new direct jobs, through research and new businesses created or moving to the region along with 10,000 indirect new jobs and about $3 billion in economic impact as a result of the investment. ....

Case Western Reserve University , United States , Mike Dewine , Scott Cowen , Tom Mihaljevic , Community Responsive Care Institute , University Hospitals , Cleveland State University , Cleveland Clinic Global Center , Pathogen Research , Global Center , Human Health , Lerner Research Institute , Case Western Reserve , Cleveland State , Cleveland Innovation District , Cleveland Clinic , Lerner Research , President Scott Cowen , Cincinnati Innovation District , வழக்கு மேற்கு இருப்பு பல்கலைக்கழகம் , ஒன்றுபட்டது மாநிலங்களில் , ஸ்காட் கோவன் , சமூக பதிலளிக்கக்கூடியது பராமரிப்பு நிறுவனம் , பல்கலைக்கழகம் மருத்துவமனைகள் , கிளீவ்லேண்ட் நிலை பல்கலைக்கழகம் ,

Endothelial TLR2 promotes proangiogenic immune cell recruitment and tumor angiogenesis

Science for just $15 USD.
A shared Toll for innate immunity
Toll-like receptor 2 (TLR2) is found in various tissues but is best known for its role in the innate immune system of activating sentinel immune cells in response to infection. Using conditional knockout mice, McCoy
et al. found that TLR2 also mediated innate immune signaling within the endothelium. TLR2 in endothelial cells activated proinflammatory signaling that promoted angiogenesis and immune cell recruitment in response to various “danger” signals, such as those produced during infection or tissue damage. Endothelial TLR2 also supported tumor growth in a mouse model of prostate cancer. These findings show that the endothelium contributes to innate immune responses and that TLR2 may be a therapeutic target in cancer (see also the Focus by Mahfoud and Petrova). ....

Antifade Mountant , Matrigel Corning , Nanodrop Thermofisher , Trizol Thermofisher , W Heston Cleveland , S Akira Osaka University , National Institutes Of Health , Institutional Biosafety Committee , Department Of Neuroscience , Lerner Research Institute , Cleveland Clinic Animal Care Committee , Jackson Laboratory , Materials Inc , Taconic Laboratories , Osaka University , Optimal Cutting Temperature , Endothelial Cell Growth Supplement , Cleveland Clinic , Proliferation Assay Kit , Applied Biological Materials , National Institutes , Gene Expression Omnibus , Alexa Fluor , Prolong Gold Antifade Mountant , Life Technologies , Thermo Fisher Scientific ,

Potential Target For Ulcerative Colitis Drugs

Potential Target For Ulcerative Colitis Drugs
by Pooja Shete on
January 15, 2021 at 7:36 PM
The study conducted by researchers from Cleveland Clinic s Lerner Research Institute is published in the journal
Nature Communications.
The researchers used this model to identify a promising target that could be blocked to slow the disease progression. Ulcerative colitis occurs due to abnormal reactions of the immune system that lead to inflammation and ulcers on the inner lining of the large intestines. The condition is highly heterogeneous both in terms of patients symptoms and disease pathology.
Current therapy for ulcerative colitis mainly focuses on suppressing the overactive immune response with anti-inflammatory drugs. However, these therapies have limited long-term efficacy in ulcerative colitis patients. ....

Emina Huang , Nature Communications , Cleveland Clinic Lerner Research Institute , Cleveland Clinic , Lerner Research Institute , Cancer Biology , Colorectal Surgery , Colitis Patients More Prone , Toxicityulcerative Colitisdrugs Banned , Ulcerative Colitis , Immune System , Chronic Inflammatory Bowel Disease , Anti Ulcerative Colitis Drugs , இயற்கை தகவல்தொடர்புகள் , கிளீவ்லேண்ட் சிகிச்சையகம் லெர்னர் ஆராய்ச்சி நிறுவனம் , கிளீவ்லேண்ட் சிகிச்சையகம் , லெர்னர் ஆராய்ச்சி நிறுவனம் , புற்றுநோய் உயிரியல் , பெருங்குடல் அறுவை சிகிச்சை , பெருங்குடல் அழற்சி நோயாளிகள் மேலும் ப்ரோந் , நோய் எதிர்ப்பு சக்தி அமைப்பு , நாள்பட்ட அழற்சி குடல் நோய் ,

Researchers engineer novel disease model to identify potential targets for ulcerative colitis drugs

CLEVELAND - As reported in
Nature Communications, researchers from Cleveland Clinic s Lerner Research Institute have developed a novel, patient-derived model of ulcerative colitis, which will help advance studies into new treatments for the chronic inflammatory bowel disease.
The team used the model to identify a promising target that could be inhibited to slow disease progression.
Ulcerative colitis is characterized by abnormal reactions of the immune system that lead to inflammation and ulcers on the inner lining of the large intestines. It is a highly heterogeneous condition, both in terms of patients symptoms and disease pathology.
Suppressing the overactive immune response with anti-inflammatory drugs is the current mainstay treatment for inflammatory bowel diseases, although these therapies have limited long-term efficacy in ulcerative colitis patients. ....

United States , Emina Huang , Samaneh Sarvestani , Nature Communications , National Institutes Of Health , Cleveland Clinic Lerner Research Institute , American Society Of Colorectal Surgeons , Surgery Institute At Cleveland Clinic , Cleveland Clinic , Lerner Research Institute , Cancer Biology , Colorectal Surgery , National Institutes , American Society , Digestive Disease , Surgery Institute , Cell Biology , Medicine Health , Clinical Trials , Immunology Allergies Asthma , Internal Medicine , Pharmaceutical Science , ஒன்றுபட்டது மாநிலங்களில் , இயற்கை தகவல்தொடர்புகள் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , கிளீவ்லேண்ட் சிகிச்சையகம் லெர்னர் ஆராய்ச்சி நிறுவனம் ,