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Potential Target For Ulcerative Colitis Drugs by Pooja Shete on January 15, 2021 at 7:36 PM The study conducted by researchers from Cleveland Clinic s Lerner Research Institute is published in the journal Nature Communications. The researchers used this model to identify a promising target that could be blocked to slow the disease progression. Ulcerative colitis occurs due to abnormal reactions of the immune system that lead to inflammation and ulcers on the inner lining of the large intestines. The condition is highly heterogeneous both in terms of patients symptoms and disease pathology. Current therapy for ulcerative colitis mainly focuses on suppressing the overactive immune response with anti-inflammatory drugs. However, these therapies have limited long-term efficacy in ulcerative colitis patients. ....
CLEVELAND - As reported in Nature Communications, researchers from Cleveland Clinic s Lerner Research Institute have developed a novel, patient-derived model of ulcerative colitis, which will help advance studies into new treatments for the chronic inflammatory bowel disease. The team used the model to identify a promising target that could be inhibited to slow disease progression. Ulcerative colitis is characterized by abnormal reactions of the immune system that lead to inflammation and ulcers on the inner lining of the large intestines. It is a highly heterogeneous condition, both in terms of patients symptoms and disease pathology. Suppressing the overactive immune response with anti-inflammatory drugs is the current mainstay treatment for inflammatory bowel diseases, although these therapies have limited long-term efficacy in ulcerative colitis patients. ....