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Insulin rises before cells develop resistance, new diabetes research implies


Credit: Johan Wingborg
Researchers at the University of Gothenburg, Sweden, have now presented results that may change our basic view of how type 2 diabetes occurs. Their study indicates that free fatty acids (FFAs) in the blood trigger insulin release even at a normal blood-sugar level, without an overt uncompensated insulin resistance in fat cells. What is more, the researchers demonstrate the connection with obesity: the amount of FFAs largely depends on how many extra kilos of adipose tissue a person carries, but also on how the body adapt to the increased adiposity.
Worldwide, extensive research is underway to clarify exactly what happens in the body as type 2 diabetes progresses, and why obesity is such a huge risk factor for the disease. For almost 50 years, diabetes researchers have been discussing their version of the chicken-or-egg question: Which comes first insulin resistance or elevated insulin levels? The dominant hypothesis has long been that the pancreas ....

Uppsala Lan , Vastra Gotalands Lan , Emanuel Fryk , Anders Jansson , Uppsala University , Sahlgrenska Academy , University Of Gothenburg , Translational Medical Research , Medicine Health , Metabolism Metabolic Diseases , ஆண்டர்ஸ் ஜான்சன் , பல்கலைக்கழகம் ஆஃப் கோடெந்ப்ர்க் , மொழிபெயர்ப்பு மருத்துவ ஆராய்ச்சி , மருந்து ஆரோக்கியம் , வளர்சிதை மாற்றம் வளர்சிதை மாற்ற நோய்கள் , நீரிழிவு நோய் ,