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HKUMed discovers a novel mediator of liver fibrosis and its underlying mechanism that can be a new therapeutic target

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HKUMed discovers a novel mediator of liver fibrosis and its underlying mechanism that can be a new therapeutic target
HKUMed discovers a novel mediator of liver fibrosis and its underlying mechanism that can be a new therapeutic target. The research was led by Dr Ruby Hoo Lai-chong (second from left), Assistant Professor, Department of Pharmacology and Pharmacy, HKUMed and Co-investigator of State Key Laboratory of Pharmaceutical Biotechnology, HKU. Dr Wu Xiaoping (second from right), post-doctoral fellow, Department of Pharmacology and Pharmacy, HKUMed is the first author. Other research team members include: Ms Zong Jiuyu (left) and Ms Zhang Zixuan (right), postgraduate student, Department of Pharmacology and Pharmacy, HKUMed. ....

United States , Hong Kong , Li Jingjing , Zong Jiuyu , Zhang Zixuan , Wang Cunchuan , Ruby Hoo Lai Chong , Shu Lingling , Wu Xiaoping , Health Bureau , Key Laboratory Of Pharmaceutical Biotechnology , University Of Hong Kong Hkumed , Research Grants Council , Department Of Medicine , Technology Program , Collaborative Research Fund , Professor Of Department Pharmacology , Drug Administration , Department Of Pharmacology , Guangdong Pharmaceutical University , Sun Yat Sen University Cancer Center , Research Program , Professor Of The Department Pharmacology , Health Medical Research Fund , First Affiliated Hospital Of Jinan University , Assistant Professor ,

[Full text] CircSKA3 Downregulates miR-1 Through Methylation in Glioblastoma to Pr

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1Department of Neurosurgery, The First Affiliated Hospital of Jinan University, Guangzhou City, Guangdong Province 510630, People’s Republic of China;
2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, People’s Republic of China
Correspondence: Xiangyu Wang
Department of Neurosurgery, The First Affiliated Hospital of Jinan University, No. 613 West Huangpu Avenue, Tianhe District, Guangzhou City, Guangdong Province 510630, People’s Republic of China
Background: Circular RNA circSKA3 plays an oncogenic role in breast cancer, while its role in glioblastoma (GBM) is unknown. This study aimed to explore the role of circSKA3 in GBM.
Methods: Differential expression of circSKA3 and miR-1 in GBM and adjacent non-cancer tissue samples were analyzed by RT-qPCR. GBM cells were transfected with circSKA3 expression vector or miR-1 mimic, followed by RT-qPCR to explore the potential crosstalk between them. Methylat ....

Eteläuomen Läi , United States , Dnasei Invitrogen , Ethics Committee , Promega Corporation , First Affiliated Hospital Of Jinan University , First Affiliated Hospital , Jinan University , Reverse Transcription System , Master Mix , Sera Xtracta Genomic , Counting Kit , Prognostic Values , Expression Levels , Proliferation Through , ஒன்றுபட்டது மாநிலங்களில் , நெறிமுறைகள் குழு , ப்ரொமெகா நிறுவனம் , முதல் இணைந்த மருத்துவமனை ஆஃப் ஜினன் பல்கலைக்கழகம் , முதல் இணைந்த மருத்துவமனை , ஜினன் பல்கலைக்கழகம் , தலைகீழ் படியெடுத்தல் அமைப்பு , குரு கலவை , எண்ணும் கிட் , வெளிப்பாடு நிலைகள் ,