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A region within GLI1 gene could potentially be targeted as cancer treatment

A region within GLI1 gene could potentially be targeted as cancer treatment
Scientists from the Stanley Manne Children s Research Institute at Ann & Robert H. Lurie Children s Hospital of Chicago found that a region within the DNA of the cancer-promoting GLI1 gene is directly responsible for regulating this gene s expression. These findings, published in the journal
Stem Cells, imply that this region within GLI1 could potentially be targeted as cancer treatment, since turning off GLI1 would interrupt excessive cell division characteristic of cancer.
From previous research, we know that GLI1 drives the unrelenting cell proliferation that is responsible for many cancers, and that this gene also stimulates its own expression. We established in living human embryonic stem cells that removing the GLI1 regulatory region eliminated GLI1 expression and halted its activity. These findings are promising and could point to a therapeutic target for cancer. ....

Philip Iannaccone , Yekaterina Galat , Emily Henderson , Manne Research Institute At Lurie Children , Manne Research Institute , Northwestern University Feinberg School Of Medicine , Stanley Manne Children , Research Institute , Stem Cells , Co Senior Author , Professor Emeritus , Lurie Children , Northwestern University Feinberg School , Research Associate , Cancer Treatment , Cell Division , Cell Proliferation , Embryonic Stem Cells , பிலிப் ஈயன்னக்கொனே , எமிலி ஹென்டர்சன் , மன்னே ஆராய்ச்சி நிறுவனம் இல் லூரி குழந்தைகள் , மன்னே ஆராய்ச்சி நிறுவனம் , வடமேற்கு பல்கலைக்கழகம் ஃபைன்பெர்க் பள்ளி ஆஃப் மருந்து , ஸ்டான்லி மன்னே குழந்தைகள் , ஆராய்ச்சி நிறுவனம் , தண்டு செல்கள் ,

Potential Target for Treating Many Cancers Found Within GLI1 Gene

Potential Target for Treating Many Cancers Found Within GLI1 Gene
newswise.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from newswise.com Daily Mail and Mail on Sunday newspapers.

Davido Walterhouse , Mariana Perepitchka , Yekaterina Galat , Igorp Beletsky , Vasiliy Galat , Haigang Gu , Xiao Nan Li , Xeniaa Glukhova , Robert Taylor , Philip Iannaccone , Stanley Manne Children Research Institute , Manne Research Institute At Lurie Children , Eisenberg Foundation For Charities , National Institutes Of Health , Manne Research Institute , Northwestern University Feinberg School Of Medicine , Stanley Manne Children , Research Institute , Stem Cells , Professor Emeritus , Lurie Children , Northwestern University Feinberg School , Research Associate , Joon Won Yoon , National Institutes , Eisenberg Foundation ,

Potential target for treating many cancers found within GLI1 gene

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Scientists from the Stanley Manne Children s Research Institute at Ann & Robert H. Lurie Children s Hospital of Chicago found that a region within the DNA of the cancer-promoting GLI1 gene is directly responsible for regulating this gene s expression. These findings, published in the journal
Stem Cells, imply that this region within GLI1 could potentially be targeted as cancer treatment, since turning off GLI1 would interrupt excessive cell division characteristic of cancer.
From previous research, we know that GLI1 drives the unrelenting cell proliferation that is responsible for many cancers, and that this gene also stimulates its own expression, says co-senior author Philip Iannaccone, MD, PhD, Professor Emeritus at the Manne Research Institute at Lurie Children s and Northwestern University Feinberg School of Medicine. We established in living human embryonic stem cells that removing the GLI1 regulatory region eliminated GLI1 expression and halted its ....

Davido Walterhouse , Mariana Perepitchka , Yekaterina Galat , Igorp Beletsky , Vasiliy Galat , Haigang Gu , Xiao Nan Li , Xeniaa Glukhova , Robert Taylor , Philip Iannaccone , Stanley Manne Children Research Institute , Manne Research Institute At Lurie Children , Eisenberg Foundation For Charities , National Institutes Of Health , Manne Research Institute , Northwestern University Feinberg School Of Medicine , Stanley Manne Children , Research Institute , Stem Cells , Professor Emeritus , Lurie Children , Northwestern University Feinberg School , Research Associate , Joon Won Yoon , National Institutes , Eisenberg Foundation ,

Nanotherapy shows potential for treating severe Crohn's disease

Nanotherapy shows potential for treating severe Crohn s disease
Scientists from the Stanley Manne Children s Research Institute at Ann & Robert H. Lurie Children s Hospital of Chicago demonstrated that a nanotherapy reduces intestinal inflammation and shrinks lesions in a rodent model of severe Crohn s disease. This approach could become an alternative to biologic antibody therapies that carry many side effects, including increased risk of certain cancers. It might also prevent the need for surgery in the future. Findings were published in the journal
Advanced Therapeutics.
Crohn s disease is an inflammatory bowel disease characterized by chronic inflammation of the digestive tract, most often in the small intestine. It can lead to intestinal obstruction and perforation, bleeding, abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition leading to growth abnormalities in children. ....

Varun Sharma , Emily Henderson , Mccormick School Of Engineering , Manne Research Institute At Lurie Children , Research Associate Professor Of Urology , Surgical Research , Stanley Manne Children , Research Institute , Senior Author , Manne Research Institute , Lurie Children , Research Associate Professor , Biomedical Engineering , Northwestern University Feinberg School , Mccormick School , Crohn 39s Disease , Anti Inflammatory , Inflammatory Bowel Disease , Small Intestine , அருண் ஷர்மா , எமிலி ஹென்டர்சன் , ம்க்கார்‌மிக் பள்ளி ஆஃப் பொறியியல் , மன்னே ஆராய்ச்சி நிறுவனம் இல் லூரி குழந்தைகள் , ஆராய்ச்சி இணை ப்ரொஃபெஸர் ஆஃப் சிறுநீரகம் , அறுவை சிகிச்சை ஆராய்ச்சி , ஸ்டான்லி மன்னே குழந்தைகள் ,

New Potential Therapy for Crohn's Disease in Children

New Potential Therapy for Crohn's Disease in Children
newswise.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from newswise.com Daily Mail and Mail on Sunday newspapers.

Varun Sharma , Stanley Manne Children Research Institute , Mccormick School Of Engineering , Research Associate Professor Of Urology , Northwestern University Feinberg School Of Medicine , Surgical Research , Manne Research Institute At Lurie Children , Manne Research Institute , Chartwell Foundation , Stanley Manne Children , Research Institute , Lurie Children , Research Associate Professor , Biomedical Engineering , Northwestern University Feinberg School , Mccormick School , அருண் ஷர்மா , ஸ்டான்லி மன்னே குழந்தைகள் ஆராய்ச்சி நிறுவனம் , ம்க்கார்‌மிக் பள்ளி ஆஃப் பொறியியல் , ஆராய்ச்சி இணை ப்ரொஃபெஸர் ஆஃப் சிறுநீரகம் , வடமேற்கு பல்கலைக்கழகம் ஃபைன்பெர்க் பள்ளி ஆஃப் மருந்து , அறுவை சிகிச்சை ஆராய்ச்சி , மன்னே ஆராய்ச்சி நிறுவனம் இல் லூரி குழந்தைகள் , மன்னே ஆராய்ச்சி நிறுவனம் , ஹார்ட்வெல் அடித்தளம் , ஸ்டான்லி மன்னே குழந்தைகள் ,