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A region within GLI1 gene could potentially be targeted as cancer treatment

A region within GLI1 gene could potentially be targeted as cancer treatment
Scientists from the Stanley Manne Children s Research Institute at Ann & Robert H. Lurie Children s Hospital of Chicago found that a region within the DNA of the cancer-promoting GLI1 gene is directly responsible for regulating this gene s expression. These findings, published in the journal
Stem Cells, imply that this region within GLI1 could potentially be targeted as cancer treatment, since turning off GLI1 would interrupt excessive cell division characteristic of cancer.
From previous research, we know that GLI1 drives the unrelenting cell proliferation that is responsible for many cancers, and that this gene also stimulates its own expression. We established in living human embryonic stem cells that removing the GLI1 regulatory region eliminated GLI1 expression and halted its activity. These findings are promising and could point to a therapeutic target for cancer. ....

Philip Iannaccone , Yekaterina Galat , Emily Henderson , Manne Research Institute At Lurie Children , Manne Research Institute , Northwestern University Feinberg School Of Medicine , Stanley Manne Children , Research Institute , Stem Cells , Co Senior Author , Professor Emeritus , Lurie Children , Northwestern University Feinberg School , Research Associate , Cancer Treatment , Cell Division , Cell Proliferation , Embryonic Stem Cells , பிலிப் ஈயன்னக்கொனே , எமிலி ஹென்டர்சன் , மன்னே ஆராய்ச்சி நிறுவனம் இல் லூரி குழந்தைகள் , மன்னே ஆராய்ச்சி நிறுவனம் , வடமேற்கு பல்கலைக்கழகம் ஃபைன்பெர்க் பள்ளி ஆஃப் மருந்து , ஸ்டான்லி மன்னே குழந்தைகள் , ஆராய்ச்சி நிறுவனம் , தண்டு செல்கள் ,

Potential Target for Treating Many Cancers Found Within GLI1 Gene

Potential Target for Treating Many Cancers Found Within GLI1 Gene
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Davido Walterhouse , Mariana Perepitchka , Yekaterina Galat , Igorp Beletsky , Vasiliy Galat , Haigang Gu , Xiao Nan Li , Xeniaa Glukhova , Robert Taylor , Philip Iannaccone , Stanley Manne Children Research Institute , Manne Research Institute At Lurie Children , Eisenberg Foundation For Charities , National Institutes Of Health , Manne Research Institute , Northwestern University Feinberg School Of Medicine , Stanley Manne Children , Research Institute , Stem Cells , Professor Emeritus , Lurie Children , Northwestern University Feinberg School , Research Associate , Joon Won Yoon , National Institutes , Eisenberg Foundation ,

Potential target for treating many cancers found within GLI1 gene

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Scientists from the Stanley Manne Children s Research Institute at Ann & Robert H. Lurie Children s Hospital of Chicago found that a region within the DNA of the cancer-promoting GLI1 gene is directly responsible for regulating this gene s expression. These findings, published in the journal
Stem Cells, imply that this region within GLI1 could potentially be targeted as cancer treatment, since turning off GLI1 would interrupt excessive cell division characteristic of cancer.
From previous research, we know that GLI1 drives the unrelenting cell proliferation that is responsible for many cancers, and that this gene also stimulates its own expression, says co-senior author Philip Iannaccone, MD, PhD, Professor Emeritus at the Manne Research Institute at Lurie Children s and Northwestern University Feinberg School of Medicine. We established in living human embryonic stem cells that removing the GLI1 regulatory region eliminated GLI1 expression and halted its ....

Davido Walterhouse , Mariana Perepitchka , Yekaterina Galat , Igorp Beletsky , Vasiliy Galat , Haigang Gu , Xiao Nan Li , Xeniaa Glukhova , Robert Taylor , Philip Iannaccone , Stanley Manne Children Research Institute , Manne Research Institute At Lurie Children , Eisenberg Foundation For Charities , National Institutes Of Health , Manne Research Institute , Northwestern University Feinberg School Of Medicine , Stanley Manne Children , Research Institute , Stem Cells , Professor Emeritus , Lurie Children , Northwestern University Feinberg School , Research Associate , Joon Won Yoon , National Institutes , Eisenberg Foundation ,